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dc.creatorGarofalo, S. (Sara)-
dc.creatorJusticia, A. (Azucena)-
dc.creatorArrondo, G. (Gonzalo)-
dc.creatorErmakova, A.O. (Anna O.)-
dc.creatorRamachandra, P. (Pranathi)-
dc.creatorTudor-Sfetea, C. (Carina)-
dc.creatorRobbins, T.W. (Trevor W.)-
dc.creatorBarker, R.A. (Roger A.)-
dc.creatorFletcher, P.C. (Paul C.)-
dc.creatorMurray, G.K. (Graham K.)-
dc.identifier.citationGarofalo, S. (Sara); Justicia, A. (Azucena); Arrondo, G. (Gonzalo); et al. "Cortical and striatal reward processing in Parkinson's disease psychosis". Frontiers in Neurology. 8 (156), 2017,es
dc.description.abstractPsychotic symptoms frequently occur in Parkinson's disease (PD), but their pathophysiology is poorly understood. According to the National Institute of Health RDoc programme, the pathophysiological basis of neuropsychiatric symptoms may be better understood in terms of dysfunction of underlying domains of neurocognition in a trans-diagnostic fashion. Abnormal cortico-striatal reward processing has been proposed as a key domain contributing to the pathogenesis of psychotic symptoms in schizophrenia. This theory has received empirical support in the study of schizophrenia spectrum disorders and preclinical models of psychosis, but has not been tested in the psychosis associated with PD. We, therefore, investigated brain responses associated with reward expectation and prediction error signaling during reinforcement learning in PD-associated psychosis. An instrumental learning task with monetary gains and losses was conducted during an fMRI study in PD patients with (n = 12), or without (n = 17), a history of psychotic symptoms, along with a sample of healthy controls (n = 24). We conducted region of interest analyses in the ventral striatum (VS), ventromedial prefrontal and posterior cingulate cortices, and whole-brain analyses. There was reduced activation in PD patients with a history of psychosis, compared to those without, in the posterior cingulate cortex and the VS during reward anticipation (p < 0.05 small volume corrected). The results suggest that cortical and striatal abnormalities in reward processing, a putative pathophysiological mechanism of psychosis in schizophrenia, may also contribute to the pathogenesis of psychotic symptoms in PD. The finding of posterior cingulate dysfunction is in keeping with prior results highlighting cortical dysfunction in the pathogenesis of PD psychosis.es_ES
dc.description.sponsorshipThis study was supported by a Medical Research Council Clinician Scientist award (G0701911), and an Isaac Newton Trust award to Dr. Murray; by support to Dr. Fletcher from the Wellcome Trust and Bernard Wolfe Health Neuroscience Fund; by a Wellcome Trust strategic award to University of Cambridge (097814/Z/11), by the NIHR Cambridge Biomedical Research Centre and University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council (G1000183) and Wellcome Trust (093875/Z/10/Z).es_ES
dc.publisherFrontiers Mediaes_ES
dc.subjectPosterior cingulate cortexes_ES
dc.subjectPrediction errores_ES
dc.subjectReinforcement learninges_ES
dc.subjectVentral striatumes_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Psiquiatría y psicologíaes_ES
dc.titleCortical and striatal reward processing in Parkinson's disease psychosises_ES
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).es_ES
dadun.citation.publicationNameFrontiers in Neurologyes_ES

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