Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Moreno-de-Viguri, E. (Elsa) | - |
dc.creator | Jimenez-Montes, C. (Carmen) | - |
dc.creator | Martin-Escolano, R. (Ruben) | - |
dc.creator | Santivañez-Veliz, M. (Mery) | - |
dc.creator | Martin-Montes, A.(Alvaro) | - |
dc.creator | Azqueta, A. (Amaya) | - |
dc.creator | Jimenez-Lopez, M. (Marina) | - |
dc.creator | Zamora-Ledesma, S. (Salvador) | - |
dc.creator | Cirauqui, N. (Nuria) | - |
dc.creator | Lopez-de-Cerain, A. (Adela) | - |
dc.creator | Marin, C. (Clotilde) | - |
dc.creator | Sanchez-Moreno, M. (Manuel) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.date.accessioned | 2018-02-28T10:50:35Z | - |
dc.date.available | 2018-02-28T10:50:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Moreno-Viguri, E. (Elsa); Jimenez-Montes, C. (Carmen); Martin-Escolano, R. (Ruben); et al. "In vitro and in vivo anti-Trypanosoma cruzi activity of new arylamine Mannich base-type derivatives". J. Med. Chem. 24 (59), 2016, 10929 - 10945 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/48346 | - |
dc.description.abstract | Chagas disease is a neglected tropical disease with 6-7 million people infected worldwide and there is no effective treatment. Therefore, there is an urgent need to continue researching in order to discover novel therapeutic alternatives. We present a series of arylaminoketone derivatives as means of identifying new drugs to treat Chagas disease in the acute phase with greater activity, less toxicity and with a larger spectrum of action than that corresponding to the reference drug benznidazole. Indexes of high selectivity found in vitro formed the basis for later in vivo assays in BALB/c mice. Murine model results show that compounds 3, 4, 7 and 10 induced a remarkable decrease in parasitemia levels in acute phase and the parasitemia reactivation following immunosuppression, and curative rates were higher than with benznidazole. These high anti-parasitic activities encourage us to propose these compounds as promising molecules for developing an easy to synthesize anti-Chagas agent. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Química | es_ES |
dc.title | In vitro and in vivo anti-Trypanosoma cruzi activity of new arylamine Mannich base-type derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1021/acs.jmedchem.6b00784 | - |
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