Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Gil-Ramirez, Y. (Yolanda) | - |
dc.creator | Raquel | - |
dc.creator | Palacios-Chaves, L. (Leyre) | - |
dc.creator | Zuñiga-Ripa, A. (Amaia) | - |
dc.creator | Grillo, M.J. (María Jesús) | - |
dc.creator | Arce-Gorvel, V. (Vilma) | - |
dc.creator | Hanniffy, S. (Sean) | - |
dc.creator | Moriyon, I. (Ignacio) | - |
dc.creator | Iriarte, M. (Maite) | - |
dc.date.accessioned | 2019-01-04T08:29:24Z | - |
dc.date.available | 2019-01-04T08:29:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Gil-Ramírez, Y. (Yolanda Teresa); Conde-Álvarez, R. (Raquel); Palacios-Chaves, L. (Leyre); et al. "The identification of wadB, a new glycosyltransferase gene, confirms the branched structure and the role in virulence of the lipopolysaccharide core of Brucella abortus". Microbial pathogenesis. 73, 2014, 53 - 59 | es |
dc.identifier.issn | 0882-4010 | - |
dc.identifier.uri | https://hdl.handle.net/10171/56052 | - |
dc.description.abstract | Brucellosis is a worldwide extended zoonosis caused by Brucella spp. These gram-negative bacteria are not readily detected by innate immunity, a virulence-related property largely linked to their surface lipopolysaccharide (LPS). The role of the LPS lipid A and O-polysaccharide in virulence is well known. Moreover, mutation of the glycosyltransferase gene wadC of Brucella abortus, although not affecting O-polysaccharide assembly onto the lipid-A core section causes a core oligosaccharide defect that increases recognition by innate immunity. Here, we report on a second gene (wadB) encoding a LPS core glycosyltransferase not involved in the assembly of the O-polysaccharide-linked core section. As compared to wild-type B. abortus, a wadB mutant was sensitive to bactericidal peptides and non-immune serum, and was attenuated in mice and dendritic cells. These observations show that as WadC, WadB is also involved in the assembly of a branch of Brucella LPS core and support the concept that this LPS section is a virulence-related structure. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Brucella | - |
dc.subject | Glycosyltransferase | - |
dc.subject | Lipopolysaccharide | - |
dc.subject | Virulence | - |
dc.subject | WadB | - |
dc.subject | WadC | - |
dc.title | The identification of wadB, a new glycosyltransferase gene, confirms the branched structure and the role in virulence of the lipopolysaccharide core of Brucella abortus | - |
dc.type | info:eu-repo/semantics/article | - |
dc.identifier.doi | 10.1016/j.micpath.2014.06.002. | - |
dadun.citation.endingPage | 59 | - |
dadun.citation.publicationName | Microbial pathogenesis | - |
dadun.citation.startingPage | 53 | - |
dadun.citation.volume | 73 | - |
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