Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study)

Pérez-Sáez, M.J. (María José); Lafuente-Covarrubias, O. (Omar); Hernández, D. (Domingo); Moreso, F. (Francesc); Melilli, E. (Edoardo); Juega, J. (Javier); Souza, E. (Erika) de; López-Sánchez, P. (Paula); Rodríguez-Ferrero, M.L. (María Luisa); Maruri-Kareaga, N. (Naroa); Navarro, M.D. (María Dolores); Valero, R. (Rosalía); Mazuecos, M.A. (María Auxiliadora); Llamas, F. (Francisco); Martín-Moreno, P.L. (Paloma L.); Fernández-García, A. (Antón); Espí, J. (Jordi); Jimenez, C. (Carlos); Ramos, A. (Ana); Gavela, E. (Eva); Pascual, J. (Julio); Portolés-Lázaro, J. (José); Grupo GEODAS

Keywords:

Materias Investigacion::Ciencias de la Salud::Medicina clínica
Kidney transplantation
Elderly donors
Donors after circulatory death
Clinical outcomes
Delayed graft function

Issue Date:

2019

Publisher:

Springer Science and Business Media LLC

ISSN:

1471-2369

Note:

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Citation:

Pérez-Sáez, M.J. (María José); Lafuente-Covarrubias, O. (Omar); Hernández, D. (Domingo); et al. "Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study)". BMC Nephrology. 20 (233), 2019, 1 - 8

Abstract

Spain has dramatically increased the number of controlled circulatory death donors (cDCD). The initial selection criteria for considering cDCD for kidney transplantation (KT) have been expanded progressively, with practically no limits in donor age during the last years. We aimed to analyze the early clinical outcomes using expanded (> 65 years) cDCD in comparison with standard ones. Observational multicenter study including 19 transplant centers in Spain. We performed a systematic inclusion in a central database of every KT from expanded cDCD at each participant unit from January-2012 to January-2017. Surgical procedures and immunosuppressive protocols were based on local practices. Data was analyzed in the central office using logistic and Cox regression or competitive-risk models for multivariate analysis. Median time of follow-up was 18.1 months. 561 KT were performed with kidneys from cDCD, 135 from donors older than 65 years. As expected, recipients from older cDCD were also older (65.8 (SD 8.8) vs 53.7 (SD 11.4) years; p < 0.001) and with higher comorbidity. At 1 year, no differences were found amongst older and younger cDCD KT recipients in terms of serum creatinine (1.6 (SD 0.7) vs 1.5 (SD 0.8) mg/dl; p = 0.29). Non-death censored graft survival was inferior, but death-censored graft survival was not different (95.5 vs 98.2% respectively; p = 0.481). They also presented a trend towards higher delayed graft function (55.4 vs 46.7%; p = 0.09) but a similar rate of primary non-function (3.7 vs 3.1%; p = 0.71), and acute rejection (3.0 vs 6.3%; p = 0.135). In the multivariate analysis, in short follow-up, donor age was not related with worse survival or poor kidney function (eGFR < 30 ml/min). The use of kidneys from expanded cDCD is increasing for older and comorbid patients. Short-term graft outcomes are similar for expanded and standard cDCD, so they constitute a good-enough source of kidneys to improve the options of KT wait-listed patients.

URI:

https://hdl.handle.net/10171/61614

DOI:

10.1186/s12882-019-1412-0

Appears in Collections:

DA - CUN - Nefrología - Artículos de revista

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