Full metadata record
DC Field | Value | Language |
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dc.creator | Raquel | - |
dc.creator | Estévez-Vázquez, O. (Olga) | - |
dc.creator | Flores-Perojo, V. (Vicente) | - |
dc.creator | Macías-Rodríguez, R.U. (Ricardo U.) | - |
dc.creator | Ruiz-Margáin, A. (Astrid) | - |
dc.creator | Martínez-Naves, E. (Eduardo) | - |
dc.creator | Regueiro, J.R. (José Ramón) | - |
dc.creator | Avila, M.A. (Matías Antonio) | - |
dc.creator | Trautwein, C. (Christian) | - |
dc.creator | Bañares, R. (Rafael) | - |
dc.creator | Bosch, J. (Jaume) | - |
dc.creator | Cubero, F.J. (Francisco Javier) | - |
dc.creator | Nevzorova, Y. (Yulia) | - |
dc.date.accessioned | 2021-10-06T07:25:42Z | - |
dc.date.available | 2021-10-06T07:25:42Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Benede Ubieto, R.; Estevez Vazquez, O.; Flores Perojo, V.; et al. "Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain". Journal of Clinical Medicine. 10 (5), 2021, 1039 | es |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62153 | - |
dc.description.abstract | The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients. | - |
dc.description.sponsorship | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | - |
dc.description.sponsorship | This work was supported by CIBERehd; grant PI16/01126 from Instituto de Salud Carlos III (ISCIII) co-financed by “Fondo Europeo de Desarrollo Regional” (FEDER) “Una manera de hacer Europa”; grant 58/17 from Gobierno de Navarra; the MINECO Retos SAF2014-54708-R, SAF2016- 78711, SAF2017-87919-R, EXOHEP-CM S2017/BMD-3727, NanoLiver-CM Y2018/NMT-4949, ERAB Ref. EA 18/14, AMMF 2018/117, UCM 25/2019, COST Action CA17112, the German Research Foundation (SFB/TRR57/P04, SFB 1382-403224013/A02 and DFG NE 2128/2-1). FJC and YAN are Ramón y Cajal Researchers RYC-2014-15242 and RYC-2015-17438, respectively. RBU is funded by the CT82/20-CT83/20 predoctoral programme UCM/Santander Universidades and OEV is an FPI associated to SAF2017-87919-R. FJC is a Gilead Liver Research Scholar. The research group belongs to the validated Research Groups Ref. 970935 ̈Liver Pathophysiology ̈and 920631 ̈Lymphocyte immunobiology ̈and IBL-6 (imas12-associated). | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | SARS-CoV-2 | - |
dc.subject | Liver injury | - |
dc.subject | Pandemic | - |
dc.subject | AST | - |
dc.subject | ALT ratio | - |
dc.subject | Ferritin | - |
dc.title | Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.identifier.doi | 10.3390/jcm10051039 | - |
dadun.citation.number | 5 | - |
dadun.citation.publicationName | Journal of Clinical Medicine | - |
dadun.citation.startingPage | 1039 | - |
dadun.citation.volume | 10 | - |
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