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dc.creatorBárcena-Varela, M. (Marina)-
dc.creatorColyn, L. (Leticia)-
dc.creatorGarcía-Fernández-de-Barrena, M. (Maite)-
dc.identifier.citationBárcena-Varela, M. (Marina); Colyn, L. (Leticia); García-Fernández-de-Barrena, M. (Maite). "Epigenetic mechanisms in hepatic stellate cell activation during liver fibrosis and carcinogenesis". International Journal of Molecular Sciences. 20 (10), 2019, 2507es_ES
dc.description.abstractLiver fibrosis is an essential component of chronic liver disease (CLD) and hepatocarcinogenesis. The fibrotic stroma is a consequence of sustained liver damage combined with exacerbated extracellular matrix (ECM) accumulation. In this context, activation of hepatic stellate cells (HSCs) plays a key role in both initiation and perpetuation of fibrogenesis. These cells suffer profound remodeling of gene expression in this process. This review is focused on the epigenetic alterations participating in the transdifferentiation of HSCs from the quiescent to activated state. Recent advances in the field of DNA methylation and post-translational modifications (PTM) of histones (acetylation and methylation) patterns are discussed here, together with altered expression and activity of epigenetic remodelers. We also consider recent advances in translational approaches, including the use of epigenetic marks as biomarkers and the promising antifibrotic properties of epigenetic drugs that are currently being used in patients.es_ES
dc.description.sponsorshipWork in the authors’ laboratory is funded by Grants SAF 2014-54191R, SAF 2017-88933R from Ministerio de Economía y Competitividad, Spain. Fundación La Caixa Hepacare Project. Fundación Eugenio Rodríguez Pascual. Fundación M. Torres. Fundación Echébano. Fundación Mario Losantos. MB-V is a fellow of Ministerio de Economía y Competitividad (BES-2015-071359); LC is a fellow of the “Gobierno de Navarra Fellowship”. The generous support of Mr. Eduardo Avila and Mr. Sergio Durá is highly appreciated.es_ES
dc.publisherMDPI AGes_ES
dc.subjectTumor microenvironmentes_ES
dc.subjectHepatic stellate cellses_ES
dc.subjectEpigenetic remodelinges_ES
dc.titleEpigenetic mechanisms in hepatic stellate cell activation during liver fibrosis and carcinogenesises_ES
dc.description.noteThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dadun.citation.publicationNameInternational Journal of Molecular Scienceses_ES

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