Full metadata record
DC Field | Value | Language |
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dc.creator | Ferrándiz-Pulido, C. (C.) | - |
dc.creator | Gómez-Tomás, A. (A.) | - |
dc.creator | Llombart, B. (B.) | - |
dc.creator | Mendoza, D. (D.) | - |
dc.creator | Marcoval, J. (J.) | - |
dc.creator | Piaserico, S. (S.) | - |
dc.creator | Baykal, C. (C.) | - |
dc.creator | Bouwes-Bavinck, J.N. (J.N.) | - |
dc.creator | Racz, E. (E.) | - |
dc.creator | Kanitakis, J. (J.) | - |
dc.creator | Harwood, C.A. (C.A.) | - |
dc.creator | Cetkovska, P. (P.) | - |
dc.creator | Geusau, A. (A.) | - |
dc.creator | Del-Marmol, V. (V.) | - |
dc.creator | Masferrer, E. (E.) | - |
dc.creator | Orte-Cano, C. (C.) | - |
dc.creator | Ricar, J. (J.) | - |
dc.creator | de-Oliveira, W.R. (W.R.) | - |
dc.creator | Salido-Vallejo, R. (Rafael) | - |
dc.creator | Ducroux, E. (E.) | - |
dc.creator | Gkini, M.A. (M.A.) | - |
dc.creator | López-Guerrero, J.A. (José Antonio) | - |
dc.creator | Kutzner, H. (H.) | - |
dc.creator | Kempf, W. (W.) | - |
dc.creator | Seckin, D. (D.) | - |
dc.date.accessioned | 2023-02-07T11:40:17Z | - |
dc.date.available | 2023-02-07T11:40:17Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Ferrándiz-Pulido, C.; Gómez-Tomás, A.; Llombart, B.; et al. "Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid-organ transplant recipients: a retrospective, multicentre cohort study". Journal of the European Academy of Dermatology and Venereology. 36 (11), 2022, 1991 - 2001 | es |
dc.identifier.issn | 0926-9959 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65294 | - |
dc.description.abstract | Background The proportion of Merkel cell carcinomas (MCCs) in solid-organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV-status and identify factors associated with tumour outcomes. Methods Retrospective, international, cohort-study. MCPyV-status was investigated by immunohistochemistry and polymerase chain reaction. Results A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs. 78 years, P < 0.001). Thirty-three percent of SOTR MCCs were MCPyV-positive vs. 91% of immunocompetent MCCs (P = 0.001). Solid-organ transplantation was associated with an increased cumulative incidence of progression (SHR: 3.35 [1.57-7.14], P = 0.002), MCC-specific mortality (SHR: 2.55 [1.07-6.06], P = 0.034) and overall mortality (HR: 3.26 [1.54-6.9], P = 0.002). MCPyV-positivity and switching to an mTOR inhibitor (mTORi) after MCC diagnosis were associated with an increased incidence of progression (SHR: 4.3 [1.5-13], P = 0.008 and SHR: 3.6 [1.1-12], P = 0.032 respectively) in SOTR. Limitations Retrospective design and heterogeneity of SOTR cohort. Conclusions MCPyV appears to play a less prominent role in the aetiopathogenesis of MCC in SOTR. SOTR have a worse prognosis than their immunocompetent counterparts and switching to an mTORi after the diagnosis of MCC does not improve progression. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.title | Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid-organ transplant recipients: a retrospective, multicentre cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License | - |
dc.identifier.doi | 10.1111/jdv.18256 | - |
dadun.citation.endingPage | 2001 | - |
dadun.citation.number | 11 | - |
dadun.citation.publicationName | Journal of the European Academy of Dermatology and Venereology | - |
dadun.citation.startingPage | 1991 | - |
dadun.citation.volume | 36 | - |
dc.identifier.pmid | 35607918 | - |
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