Full metadata record
DC Field | Value | Language |
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dc.creator | Verbakel, J.Y. (Jan Yvan) | - |
dc.creator | Heremans, R. (Ruben) | - |
dc.creator | Wynants, L. (Laure) | - |
dc.creator | Epstein, E. (Elizabeth) | - |
dc.creator | Cock, B. (Bavo) de | - |
dc.creator | Pascual, M.A. (Maria Angela) | - |
dc.creator | Leone, F.P.G. (Francesco Paolo Giuseppe) | - |
dc.creator | Sladkevicius, P. (Povilas) | - |
dc.creator | Alcazar, J.L. (Juan Luis) | - |
dc.creator | Pachterbeke, C. (Catherine) van | - |
dc.creator | Jokubkiene, L. (Ligita) | - |
dc.creator | Fruscio, R. (Robert) | - |
dc.creator | Bourne, T. (Tom) | - |
dc.creator | Calster, B. (Ben) van | - |
dc.creator | Timmerman, D. (Dirk) | - |
dc.creator | Bosch, T. (Thierry) van den | - |
dc.date.accessioned | 2023-02-07T12:40:47Z | - |
dc.date.available | 2023-02-07T12:40:47Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Verbakel, J. Y.; Heremans, R.; Wynants, L.; et al. "Risk assessment for endometrial cancer in women with abnormal vaginal bleeding: results from the prospective IETA-1 cohort study". International Journal of Gynecology and Obstetrics. 159 (1), 2022, 103 - 110 | es |
dc.identifier.issn | 0020-7292 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65300 | - |
dc.description.abstract | Objective To investigate the association between personal history, anthropometric features and lifestyle characteristics and endometrial malignancy in women with abnormal vaginal bleeding. Methods Prospective observational cohort assessed by descriptive and multivariable logistic regression analyses. Three features-age, body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters), and nulliparity-were defined a priori for baseline risk assessment of endometrial malignancy. The following variables were tested for added value: intrauterine contraceptive device, bleeding pattern, age at menopause, coexisting diabetes/hypertension, physical exercise, fat distribution, bra size, waist circumference, smoking/drinking habits, family history, use of hormonal/anticoagulant therapy, and sonographic endometrial thickness. We calculated adjusted odds ratio, optimism-corrected area under the receiver operating characteristic curve (AUC), R-2, and Akaike's information criterion. Results Of 2417 women, 155 (6%) had endometrial malignancy or endometrial intraepithelial neoplasia. In women with endometrial cancer median age was 67 years (interquartile range [IQR] 56-75 years), median parity was 2 (IQR 0-10), and median BMI was 28 (IQR 25-32). Age, BMI, and parity produced an AUC of 0.82. Other variables marginally affected the AUC, adding endometrial thickness substantially increased the AUC in postmenopausal women. Conclusion Age, parity, and BMI help in the assessment of endometrial cancer risk in women with abnormal uterine bleeding. Other patient information adds little, whereas sonographic endometrial thickness substantially improves assessment. | - |
dc.description.sponsorship | The study was supported by Flemish Governmental grant of the Institute for the Promotion of Innovation by Science and Technology (Innovatie door Wetenschap en Technologie, IWTFlanders): Applied Biomedical Research with a Primary Social finality (TBM) IETA (grant no. 130256), and KU Leuven Internal Funds (grant no. C16/15/059). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. LW is a postdoctoral fellow of the Scientific Research Fund Flanders (FWO). DT and TVdB are senior clinical investigators of the FWO. We thank Lil Valentin for her editorial support. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Endometrial neoplasms | - |
dc.subject | Endometrium | - |
dc.subject | Uterine hemorrhage | - |
dc.title | Risk assessment for endometrial cancer in women with abnormal vaginal bleeding: results from the prospective IETA-1 cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License | - |
dc.identifier.doi | 10.1002/ijgo.14097 | - |
dadun.citation.endingPage | 110 | - |
dadun.citation.number | 1 | - |
dadun.citation.publicationName | International Journal of Gynecology and Obstetrics | - |
dadun.citation.startingPage | 103 | - |
dadun.citation.volume | 159 | - |
dc.identifier.pmid | 35044676 | - |
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