Full metadata record
DC Field | Value | Language |
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dc.creator | Arredondo-Montero, J. (Javier) | - |
dc.creator | Antona, G. (Giuseppa) | - |
dc.creator | Bardají-Pascual, C. (Carlos) | - |
dc.creator | Bronte-Anaut, M. (Mónica) | - |
dc.creator | Ros-Briones, R. (Raquel) | - |
dc.creator | Fernández-Celís, A. (Amaya) | - |
dc.creator | Rivero-Marcotegui, A. (Adriana) | - |
dc.creator | Lopez-Andres, N. (Natalia) | - |
dc.creator | Martin-Calvo, N. (Nerea) | - |
dc.date.accessioned | 2023-03-20T11:45:28Z | - |
dc.date.available | 2023-03-20T11:45:28Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Arredondo-Montero, J. (Javier); Antona, G. (Giuseppa); Bardají-Pascual, C. (Carlos); et al. "Serum neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic tool in pediatric acute appendicitis: a prospective validation study". Pediatric Surgery International. 38 (11), 2022, 1569 - 1576 | es_ES |
dc.identifier.issn | 1437-9813 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65742 | - |
dc.description.abstract | Introduction: NGAL has recently been studied as a biomarker in the diagnostic context of pediatric acute appendicitis (PAA), although existing series are scarce and have limited sample sizes. Materials and methods: A prospective observational study was designed to validate serum NGAL as a diagnostic tool in PAA. This study included 215 patients, divided into 3 groups: (1) patients undergoing major outpatient surgery (n: 63), (2) patients with non-surgical abdominal pain in whom a diagnosis of PAA was excluded (n: 53) and (3) patients with a confirmed diagnosis of PAA (n: 99). Patients in group 3 were divided into complicated or uncomplicated appendicitis. In 201 patients, a serum sample was obtained at the time of diagnosis and NGAL concentration was determined by ELISA. The Kolmogorov-Smirnov test was used to assess normality. Comparative statistical analyses were performed using the Mann-Whitney U test, the Kruskal-Wallis test and the Fisher's exact test. To calculate the discriminative ability of the molecule, the area under the receiver-operating characteristic curves (AUC) was calculated. A p value < 0.05 established statistical significance. Results: Median (interquartile range) of serum NGAL values were 38.88 (27.15-48.04) ng/mL (group 1), 51.84 (37.33-69.80) ng/mL (group 2) and 65.06 (50.50-86.60) ng/mL (group 3). The AUC (group 2 vs 3) was 0.642 (95% CI 0.542-0.741) (p < 0.001) and the best cutoff point was found to be at 40.97 ng/mL, with a sensitivity of 89% and a specificity of 34.6%. No statistically significant differences in serum NGAL values were found between patients with uncomplicated PAA and those with complicated PAA. Conclusions: This prospective validation study with a large sample size confirms that the diagnostic yield of NGAL in the context of PAA is only moderate, and therefore, it should not be used as a unique diagnostic tool. Furthermore, NGAL is not a valid biomarker to discern between uncomplicated and complicated PAA. | es_ES |
dc.description.sponsorship | Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | 24p3 | es_ES |
dc.subject | AUC | es_ES |
dc.subject | Diagnostic | es_ES |
dc.subject | Gelatinase | es_ES |
dc.subject | LCN2 | es_ES |
dc.subject | Lipocalin | es_ES |
dc.subject | NGAL | es_ES |
dc.subject | Neutrophil | es_ES |
dc.subject | Pediatric acute appendicitis | es_ES |
dc.subject | ROC | es_ES |
dc.subject | Sensitivity | es_ES |
dc.subject | Siderocalin | es_ES |
dc.subject | Specificity | es_ES |
dc.title | Serum neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic tool in pediatric acute appendicitis: a prospective validation study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is licensed under a Creative Commons Attribution 4.0 International License | es_ES |
dc.identifier.doi | 10.1007/s00383-022-05197-w | - |
dadun.citation.endingPage | 1576 | es_ES |
dadun.citation.number | 11 | es_ES |
dadun.citation.publicationName | Pediatric Surgery International | es_ES |
dadun.citation.startingPage | 1569 | es_ES |
dadun.citation.volume | 38 | es_ES |
dc.identifier.pmid | 35972539 | - |
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