The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life

Deodati, A. (Annalisa); Argemí, J. (Josepmaria); Germani, D. (Daniela); Puglianiello, A. (Antonella); Alisi, A. (Anna); Stefanis, C. (Cristiano); Ferrero, R. (Roberto); Nobili, V. (Valerio); Aragón-Amonárriz, T. (Tomás); Cianfarani, S. (Stefano)

Palabras clave :

Chronic diseases
Adult life
Unfolded protein response (UPR)

Fecha de publicación :

2018

Editorial :

Plos One

ISSN :

1932-6203

Nota:

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cita:

Deodati, A. (Annalisa); Argemí, J. (Josepmaria); Germani, D. (Daniela); et al. "The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life". Plos one. 13 (6), 2018, e0198490

Resumen

Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an animal model of intrauterine growth restriction (IUGR).

URI :

https://hdl.handle.net/10171/65811

DOI:

10.1371/journal.pone.0198490

Aparece en las colecciones:

DA - CIMA - Hepatología - Hepatología del cáncer - Artículos de revista

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