Full metadata record
DC Field | Value | Language |
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dc.creator | Villarejo-Galende, A. (Alberto) | - |
dc.creator | García-Arcelay, E. (Elena) | - |
dc.creator | Pinol-Ripoll, G. (Gerard) | - |
dc.creator | Olmo-Rodríguez, A. (Antonio) del | - |
dc.creator | Viñuela, F. (Felix) | - |
dc.creator | Boada, M. (Mercè) | - |
dc.creator | Franco-Macias, E. (Emilio) | - |
dc.creator | Ibáñez-de-la-Pena, A. (Almudena) | - |
dc.creator | Riverol-Fernández, M. (M.) | - |
dc.creator | Abizanda-Soler, P. (Pedro) | - |
dc.creator | Arroyo, R. (Rafael) | - |
dc.creator | Baquero-Toledo, M. (Miguel) | - |
dc.creator | Feria-Vilar, I. (Inmaculada) | - |
dc.creator | Balasa, M. (Mircea) | - |
dc.creator | Berbel, Á. (Ángel) | - |
dc.creator | Rodríguez-Rodríguez, E. (Eloy) | - |
dc.creator | Vieira-Camposs, A. (Alba) | - |
dc.creator | García-Ribas, G. (G.) | - |
dc.creator | Rodrigo-Herrero, S. (Silvia) | - |
dc.creator | Terrancle, Á. (Ángeles) | - |
dc.creator | Prefasi, D. (Daniel) | - |
dc.creator | Lleó, A. (Alberto) | - |
dc.creator | Maurino, J. (Jorge) | - |
dc.date.accessioned | 2023-04-19T12:49:59Z | - |
dc.date.available | 2023-04-19T12:49:59Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Villarejo-Galende, A.; García-Arcelay, E.; Pinol-Ripoll, G.; et al. "Quality of life and the experience of living with early-stage Alzheimer's disease". Journal Of Alzheimers Disease. 90 (2), 2022, 719 - 726 | es |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://hdl.handle.net/10171/66024 | - |
dc.description.abstract | Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score >= 22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5-1.0. The Quality of Life in Alzheimer ' s Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment. | - |
dc.description.sponsorship | This study was funded by the Medical Department of Roche Farma Spain (ML42346). | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Área de Medicina Clínica y Epidemiología | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Depression | - |
dc.subject | Early-stage | - |
dc.subject | Hopelessness | - |
dc.subject | Quality of life | - |
dc.subject | Stigma | - |
dc.title | Quality of life and the experience of living with early-stage Alzheimer's disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.relation.publisherversion | https://pubmed.ncbi.nlm.nih.gov/36155523/ | - |
dc.description.note | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). | - |
dc.identifier.doi | 10.3233/JAD-220696 | - |
dadun.citation.endingPage | 726 | - |
dadun.citation.number | 2 | - |
dadun.citation.publicationName | JOURNAL OF ALZHEIMERS DISEASE | - |
dadun.citation.startingPage | 719 | - |
dadun.citation.volume | 90 | - |
dc.identifier.pmid | 36155523 | - |
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