Full metadata record
DC Field | Value | Language |
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dc.creator | Tamariz-Amador, L.E. (Luis Esteban) | - |
dc.creator | Rodriguez-Otero, P. (Paula) | - |
dc.creator | Jiménez-Ubieto, A. (Ana) | - |
dc.creator | Rosiñol, L. (Laura) | - |
dc.creator | Oriol, A. (Albert) | - |
dc.creator | Ríos, R. (Rafael) de los | - |
dc.creator | Sureda-Balari, A. M. (Anna Maria) | - |
dc.creator | Blanchard, M.J. (María Jesús) | - |
dc.creator | Hernandez, M.T. (Miguel Teodoro) | - |
dc.creator | Cabañas, V. (Valentín) | - |
dc.creator | Jarque, I. (Isidro) | - |
dc.creator | Bargay, J. (Joan) | - |
dc.creator | Gironella, M. (Mercedes) | - |
dc.creator | Arriba, F. (Felipe) de | - |
dc.creator | Palomera, L. (Luis) | - |
dc.creator | Gonzalez-Montes, Y. (Yolanda) | - |
dc.creator | Marti, J.M. (J.M.) | - |
dc.creator | Krsnik, I. (Isabel) | - |
dc.creator | Arguiñano, J.M. (José María) | - |
dc.creator | González, M.E. (María Esther) | - |
dc.creator | Casado, L.F. (Luis Felipe) | - |
dc.creator | González-Rodriguez, A.P. (Ana Pilar) | - |
dc.creator | Lopez-Anglada, L. (Lucia) | - |
dc.creator | Puig, N. (Noemí) | - |
dc.creator | Cedena, M.T. (María Teresa) | - |
dc.creator | Lourenco-Paiva, B.D. (Bruno David) | - |
dc.creator | Mateos, M.V. (María Victoria) | - |
dc.creator | San-Miguel-Izquierdo, J. (Jesús Fernando) | - |
dc.creator | Lahuerta, J.J. (Juan José) | - |
dc.creator | Bladé, J. (Joan) | - |
dc.creator | Troconiz, I.F. (Iñaki F.) | - |
dc.date.accessioned | 2023-04-19T15:57:41Z | - |
dc.date.available | 2023-04-19T15:57:41Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Tamariz-Amador, L. (Luis Esteban); Rodríguez-Otero, P. (Paula); Jiménez-Ubieto, A.; et al. "Prognostic value of serum paraprotein response kinetics in patients with newly diagnosed multiple myeloma". Clinical Lymphoma Myeloma And Leukemia. 22 (9), 2022, e844 - e852 | es |
dc.identifier.issn | 2152-2669 | - |
dc.identifier.uri | https://hdl.handle.net/10171/66032 | - |
dc.description.abstract | Introduction: Response kinetics is a well-established prognostic marker in acute lymphoblastic leukemia. The situation is not clear in multiple myeloma (MM) despite having a biomarker for response monitoring (monoclonal component [MC]). Materials and Methods: We developed a mathematical model to assess the prognostic value of serum MC response kinetics during 6 induction cycles, in 373 NDMM transplanted patients treated in the GEM2012Menos65 clinical trial. The model calculated a ¿resistance¿ parameter that reflects the stagnation in the response after an initial descent. Results: Two patient subgroups were defined based on low and high resistance, that respectively captured sensitive and refractory kinetics, with progression-free survival (PFS) at 5 years of 72% and 59% (HR 0.64, 95% CI 0.44-0.93; P =.02). Resistance significantly correlated with depth of response measured after consolidation (80.9% CR and 68.4% minimal residual disease negativity in patients with sensitive vs. 31% and 20% in those with refractory kinetics). Furthermore, it modulated the impact of reaching CR after consolidation; thus, within CR patients those with refractory kinetics had significantly shorter PFS than those with sensitive kinetics (median 54 months vs. NR; P =.02). Minimal residual disease negativity abrogated this effect. Our study also questions the benefit of rapid responders compared to late responders (5-year PFS 59.7% vs. 76.5%, respectively [P <.002]). Of note, 85% of patients considered as late responders were classified as having sensitive kinetics. Conclusion: This semi-mechanistic modeling of M-component kinetics could be of great value to identify patients at risk of early treatment failure, who may benefit from early rescue intervention strategies. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Área de Medicina Clínica y Epidemiología | - |
dc.subject | Early treatment failure | - |
dc.subject | Newly diagnosed myeloma | - |
dc.subject | Time to best response | - |
dc.subject | Prognostic marker | - |
dc.subject | Depht of response | - |
dc.title | Prognostic value of serum paraprotein response kinetics in patients with newly diagnosed multiple myeloma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.relation.publisherversion | https://pubmed.ncbi.nlm.nih.gov/35688793/ | - |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | - |
dc.identifier.doi | 10.1016/j.clml.2022.04.024 | - |
dadun.citation.endingPage | e852 | - |
dadun.citation.number | 9 | - |
dadun.citation.publicationName | CLINICAL LYMPHOMA MYELOMA AND LEUKEMIA | - |
dadun.citation.startingPage | e844 | - |
dadun.citation.volume | 22 | - |
dc.identifier.pmid | 35688793 | - |
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