Full metadata record
DC Field | Value | Language |
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dc.creator | Calvo, F.A. (Felipe A.) | - |
dc.creator | Asencio, J.M. (José Manuel) | - |
dc.creator | Roeder, F. (Falk) | - |
dc.creator | Krempien, R. (Robert) | - |
dc.creator | Poortmans, P. (Philip) | - |
dc.creator | Hensley, F.W. (Frank W.) | - |
dc.creator | Krengli, M. (Marco) | - |
dc.date.accessioned | 2023-05-16T12:09:29Z | - |
dc.date.available | 2023-05-16T12:09:29Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Calvo, F.A. (Felipe A.); Asencio, J.M. (José Manuel); Roeder, F. (Falk); et al. "ESTRO IORT Task Force/ACROP recommendations for intraop". Clinical and Translational Radiation Oncology. 23, 2020, 91 - 99 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/66264 | - |
dc.description.abstract | Radiation therapy (RT) is a valuable component of multimodal treatment for localized pancreatic cancer. Intraoperative radiation therapy (IORT) is a very precise RT modality to intensify the irradiation effect for cancer involving upper abdominal structures and organs, generally delivered with electrons (IOERT). Unresectable, borderline and resectable disease categories benefit from dose-escalated chemoradiation strategies in the context of active systemic therapy and potential radical surgery. Prolonged preoperative treatment may act as a filter for selecting patients with occult resistant metastatic disease. Encouraging survival rates have been documented in patients treated with preoperative chemoradiation followed by radical surgery and IOERT (>20 months median survival, >35% survival at 3 years). Intensive preoperative treatment, including induction chemotherapy followed by chemoradiation and an IOERT boost, appears to prolong long-term survival within the subset of patients who remain relapse-free for>2 years (>30 months median survival; >40% survival at 3 years). Improvement of local control through higher RT doses has an impact on the survival of patients with a lower tendency towards disease spread. IOERT is a well-accepted approach in the clinical scenario (maturity and reproducibility of results), and extremely accurate in terms of dose-deposition characteristics and normal tissue sparing. The technique can be adapted to systemic therapy and surgical progress. International guidelines (National Comprehensive Cancer Network or NCCN guidelines) currently recommend use of IOERT in cases of close surgical margins and residual disease. We hereby report the ESTRO/ACROP recommendations for performing IOERT in borderline-resectable pancreatic cancer. | es_ES |
dc.description.sponsorship | Jose M. Asencio Is member of the IOeRT Consortium, established on 21 December 2019, supported by Sordina IORT Technologies spa Felipe A. Calvo: Is member of the IOeRT Consortium, established on 21 December 2019, supported by Sordina IORT Technologies spa Philip Poortmans Is member of the IOeRT Consortium, established on 21 December 2019, supported by Sordina IORT Technologies spa Is medical advisor of Sordina IORT Technologies spa, starting from 1 April 2020 on Marco Krengli Received travel grants from IntraOp Medical Corporation, CA, USA | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Pancreatic cancer | es_ES |
dc.subject | Borderline | es_ES |
dc.subject | Intraoperative radiotherapy | es_ES |
dc.subject | IORT | es_ES |
dc.subject | IOERT | es_ES |
dc.subject | Electron beam | es_ES |
dc.subject | Pancreatic resection | es_ES |
dc.title | ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy in borderline-resected pancreatic cancer | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). | es_ES |
dc.identifier.doi | 10.1016/j.ctro.2020.05.005 | - |
dadun.citation.endingPage | 99 | es_ES |
dadun.citation.publicationName | Clinical and Translational Radiation Oncology | es_ES |
dadun.citation.startingPage | 91 | es_ES |
dadun.citation.volume | 23 | es_ES |
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