Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Grünewald, T.G.P. (Thomas G. P.) | - |
dc.creator | Alonso-Roldán, M.M. (Marta María) | - |
dc.creator | Avnet, S. (Sofia) | - |
dc.creator | Banito, A. (Ana) | - |
dc.creator | Burdach, S. (Stefan) | - |
dc.creator | Cidre-Aranaz, F. (Florencia) | - |
dc.creator | Di-Pompo, G. (Gemma) | - |
dc.creator | Distel, M. (Martin) | - |
dc.creator | Dorado-Garcia, H. (Heathcliff) | - |
dc.creator | Garcia-Castro, J. (Javier) | - |
dc.creator | González-González, L. (Laura) | - |
dc.creator | Grigoriadis, A.E. (Agamemnon) | - |
dc.creator | Kasan, M. (Merve) | - |
dc.creator | Koelsche, C. (Christian) | - |
dc.creator | Krumbholz, M. (Manuela) | - |
dc.creator | Lecanda, F. (Fernando) | - |
dc.creator | Lemma, S. (Silvia) | - |
dc.creator | Longo, D.L. (Dario L.) | - |
dc.creator | Madrigal-Esquivel, C. (Claudia) | - |
dc.creator | Morales-Molina, Á. (Álvaro) | - |
dc.creator | Musa, J. (Julian) | - |
dc.creator | Ohmura, S. (Shunya) | - |
dc.creator | Ory, B. (Benjamin) | - |
dc.creator | Pereira-Silva, M. (Miguel) | - |
dc.creator | Perut, F. (Francesca) | - |
dc.creator | Rodríguez, R. (René) | - |
dc.creator | Seeling, C. (Carolin) | - |
dc.creator | Al-Shaaili, N. (Nada) | - |
dc.creator | Shaabani, S. (Shabnam) | - |
dc.creator | Shiavone, K. (Kristina) | - |
dc.creator | Sinha, S. (Snehadri) | - |
dc.creator | Tomazou, E.M. (Eleni M.) | - |
dc.creator | Trautmann, M. (Marcel) | - |
dc.creator | Vela, M. (Maria) | - |
dc.creator | Versleijen-Jonkers, Y.M.H. (Yvonne M. H.) | - |
dc.creator | Visgauss, J. (Julia) | - |
dc.creator | Zalacain, M. (Marta) | - |
dc.creator | Schober, S.J. (Sebastian J.) | - |
dc.creator | Lissat, A. (Andrej) | - |
dc.creator | English, W.R. (William R.) | - |
dc.creator | Baldini, N. (Nicola) | - |
dc.creator | Heymann, D. (Dominique) | - |
dc.date.accessioned | 2023-05-30T07:33:59Z | - |
dc.date.available | 2023-05-30T07:33:59Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Grünewald, T.G.P. (Thomas G. P.); Alonso, M. (Marta); Avnet, S. (Sofia); et al. "Sarcoma treatment in the era of molecular medicine". Embo molecular medicine. 12 (11), 2020, e11131 | es |
dc.identifier.issn | 1757-4676 | - |
dc.identifier.uri | https://hdl.handle.net/10171/66462 | - |
dc.description.abstract | Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma. | es_ES |
dc.description.sponsorship | The authors thank the European EuSARC initiative, which addresses the clinical challenges posed by sarcomas and aims at accelerating the translation of new molecular findings into clinical practice through the organization of annual conferences that foster interdisciplinary and international collaboration in the field of sarcomas (www.eusarc.com) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cancer stem cells | es_ES |
dc.subject | Cell dormancy | es_ES |
dc.subject | Chorioallantoic membrane (CAM) models | es_ES |
dc.subject | Circulating tumor cells (CTCs) | es_ES |
dc.subject | Epigenomic alterations | es_ES |
dc.subject | Extracellular vesicles (EVs) | es_ES |
dc.subject | Genomic alterations | es_ES |
dc.subject | Immunotherapy | es_ES |
dc.subject | Oncolytic viruses | es_ES |
dc.subject | Orthotopic xenografts | es_ES |
dc.subject | Patient-derived xenografts (PDXs) | es_ES |
dc.subject | Pediatric tumors | es_ES |
dc.subject | Precision medicine | es_ES |
dc.subject | Sarcomas | es_ES |
dc.subject | Tumor microenvironment (TME) | es_ES |
dc.title | Sarcoma treatment in the era of molecular medicine | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.identifier.doi | 10.15252/emmm.201911131 | - |
dadun.citation.number | 11 | es_ES |
dadun.citation.publicationName | Embo molecular medicine | es_ES |
dadun.citation.startingPage | e11131 | es_ES |
dadun.citation.volume | 12 | es_ES |
dc.identifier.pmid | 33047515 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.