COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?
Respiratory system
Procoagulant state
Issue Date: 
Springer Nature
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Ferrandis, R. (Raquel); Llau, J.V. (Juan V.); Quintana, M. (Manuel); et al. "COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?". Critical care. 24 (332), 2020,
The novel infection caused by coronavirus SARS-CoV-2 determining COVID-19 disease causes alterations mainly in the respiratory system. Many reports have postulated a procoagulant state accompanying the respiratory distress with thrombosis at both venous and arterial levels [1]. The procoagulant pattern is characterized by hyperfibrinogenemia and elevated D-dimer levels, with mild thrombocytopenia and a moderately prolonged prothrombin time [2]. Although D-dimers are not specific indicators of clot formation, in combination with the other parameters, its elevation may suggest a systemic coagulation activation with an increase of thrombin generation and fibrinolysis.

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