Vitamin D status and parathyroid hormone assessment in girls with central precocious puberty

Abstract

Purpose The objective of this study was to analyze vitamin D status and PTH concentrations in 6- to 8-year-old girls with central precocious puberty. Methods A cross-sectional clinical and blood testing study (calcium, phosphorus, 25(OH)D and PTH) was carried out in 78 girls with central precocious puberty (CPP group), aged 6.1–7.9 years. A control group was recruited (137 prepubertal girls, aged 6.1–8.2 years). The criteria of the US Endocrine Society were used for the defnition of hypovitaminosis D. Results There were no signifcant diferences in vitamin D status between both groups. There were no signifcant diferences in 25(OH)D concentrations between CPP (25.4±8.6 ng/mL) and control groups (28.2±7.4 ng/mL). In contrast, PHT concentrations in CPP group (44.8±16.3 pg/mL) were higher (p<0.05) with respect to control group (31.0±11.9 ng/mL). In CPP group, there was a positive correlation (p<0.05) between PTH concentrations and growth rate, bone age, and basal estradiol, basal FSH, basal LH and LH peak concentrations. Conclusion Vitamin D status in 6- to 8-year-old girls with CPP is similar to that in prepubertal girls. PTH concentrations were signifcantly higher in girls with CPP, and this could be considered as a physiological characteristic of puberty and, in this case, of pubertal precocity