Functional study of chromatin factors uncovers strong lineage determining roles and divergent behaviours between normal and malignant haematopoiesis
Keywords: 
Materias Investigacion::Ciencias de la vida::Genética
Genome regulatory mechanisms
Haematopoiesis
Malignant haematopoiesis
Issue Date: 
18-Jan-2024
Defense Date: 
2-Nov-2023
Publisher: 
Universidad de Navarra
Citation: 
GOÑI, Ainhoa. "Functional study of chromatin factors uncovers strong lineage determining roles and divergent behaviours between normal and malignant haematopoiesis". Pineda, A. y Lara, D. (dirs.). Tesis doctoral. Universidad de Navarra, Pamplona, 2023.
Abstract
The development of eukaryotic organisms requires the coordination of dynamic regulatory programs at multiple levels, including transcription, post-transcription and translation 1–3 . Understanding the genome regulatory networks is essential to unravel the transcriptional control mechanisms of cell-fate choices and identity during cellular differentiation and development, cell homeostasis, metabolism, inheritance and external stimuli response 4–6 . In addition, genome regulatory elements overlap with a significant fraction of genetic variants associated with pathological conditions such as congenital diseases and cancer 1. Thus, they are currently at the forefront of new therapeutic approaches 1,7,8. When discussing genome regulation, six primary layers of regulation must be considered. These encompass the presence of 1) cis-regulatory elements, including promoters and enhancers, 2) transcription and chromatin factors (TFs and CFs, respectively), and 3) epigenetic tags, such as DNA and histone modifications; 4) the intricate interactions between TFs and CFs in activating or repressing specific genome regulatory elements; 5) long non-coding RNAs (lncRNAs); and 6) the re-configuration of the three-dimensional (3D) chromatin structure 9–11. The integration of these layers culminates in a specific transcriptional program that supports the unique cellular identities.

Files in This Item:
Thumbnail
File
Tesis_Goñi.pdf
Description
Size
33.12 MB
Format
Adobe PDF


Statistics and impact
0 citas en
0 citas en

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.