(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Effects of the whole seed and a protein isolate of faba bean (Vicia faba) on the cholesterol metabolism of hypercholesterolaemic rats
Autor(es) : Macarulla, M.T. (M. Teresa)
Medina, C. (César)
Diego, M.A. (Maria Arántzazu)
Chavarri, M. (M.)
Zulet, M.A. (María Ángeles)
Martinez, J.A. (Jose Alfredo)
Nöel-Suberville, C. (Catherine)
Higueret, P. (P.)
Portillo, M.P. (María P.)
Palabras clave : Faba bean
Protein isolate
Hypercholesterolaemia
Fecha incorporación: 2001
Editorial : Cambridge University Press
Versión del editor: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=893748
ISSN: 0007-1145
Cita: Macarulla MT, Medina C, De Diego MA, Chavarri M, Zulet MA, Martinez JA, et al. Effects of the whole seed and a protein isolate of faba bean (Vicia faba) on the cholesterol metabolism of hypercholesterolaemic rats. Br J Nutr 2001 May;85(5):607-614.
Resumen
The aim of the present work was to analyse the hypocholesterolaemic efficiency of a Vicia fabaprotein isolate in relation to the intact legume. In addition, the mechanisms underlying the effects of this isolate were investigated. Hypercholesterolaemic rats were divided into three groups n10 3 and fed high-fat diets rich in cholesterol-containing casein, whole seeds of Vicia faba or the protein isolate of faba beans as protein source, for 2 weeks ad libitum. The protein isolate was prepared by isoelectric precipitation and spray dried. Analyses of serum, liver and faeces, as well as of the activity of hepatic 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, were assessed by enzymatic methods. The rats fed on Vicia faba diets showed significantly lower body weights and energy intakes than rats fed on casein diets. The wholeseed diet induced a significant reduction in plasma triacylglycerol. Feeding rats on diets containing faba bean seeds, or the protein isolate, induced a significant decrease in plasma (LDL+VLDL)-cholesterol but not in HDL-cholesterol. Hepatic cholesterol and triacylglycerol were also reduced. The hypocholesterolaemic effects of Vicia faba were not the result of a reduction in cholesterol synthesis as assessed from HMG-CoA reductase activity, but the result of an increase in steroid faecal excretion. The faba bean-protein isolate obtained under our experimental conditions was useful in improving the metabolic alterations induced by feeding with a hypercholesterolaemic diet compared with casein. The effectiveness of the whole seeds was higher than that of the protein isolate.
Enlace permanente: http://hdl.handle.net/10171/17592
Aparece en las colecciones: DA - Farmacia - CAFT - Artículos de revista

Ficheros en este registro:
Fichero:  BritJNutr2001.pdf
Descripción: 
Tamaño:  175,97 kB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.