(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors
Autor(es) : Moleres, A. (Adriana)
Rendo-Urteaga, T. (Tara)
Azcona, C. (C.)
Martinez, J.A. (Jose Alfredo)
Gomez-Martinez, S. (Sonia)
Ruiz, J.R. (J.R.)
Moreno, L.A. (Luis A.)
Marcos, A. (Ascensión)
Marti, A. (Amelia)
Palabras clave : Obesity
Adolescents
Polymorphism
IL6
Fecha incorporación: 2009
Editorial : Springer Verlag
Versión del editor: http://dx.doi.org/10.1007/BF03185936
ISSN: 1138-7548
Cita: Moleres A, Rendo-Urteaga T, Azcona C, Martinez JA, Gomez-Martinez S, Ruiz JR, et al. Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors. J Physiol Biochem. 2009 Dec;65(4):405-13.
Resumen
During the last decades, the prevalence of obesity has increased rapidly among young people. A polymorphism in the promoter region of the IL6 gene (-174G/C), has been previously reported to be involved in obesity and metabolic syndrome development. Therefore, the aim of the study was to examine whether the IL6 -174G/C polymorphism influence the association of body fat with low-grade inflammatory markers and blood lipids and lipoproteins in Spanish adolescents. 504 Spanish adolescents participating in the AVENA study were genotyped for the -174G/C polymorphism of the IL6 gene. Anthropometric and body composition measurements were taken and blood samples were collected for plasma molecules determinations. No differences between genotypes were observed in anthropometric values, body composition measurements and plasma markers concentration. Physical activity level differ between genotypes with subjects carrying the C allele of the polymorphism being significantly (p<0.05) more active than GG subjects. The association between body fat mass and plasma glucose was influenced by the -174G/C polymorphism of the IL6 gene. Subjects carrying the C allele of the mutation seem to have higher values of lipoprotein (a) and C-reactive protein as their percentage of body fat mass increase. Our results suggest that this promoter polymorphism influences the association between adiposity and some plasma markers.
Enlace permanente: http://hdl.handle.net/10171/19252
Aparece en las colecciones: DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - Farmacia - CAFT - Artículos de revista

Ficheros en este registro:
Fichero:  ArtículoAMoleres.pdf
Descripción: 
Tamaño:  107,19 kB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.