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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors
Otros títulos : Correlación entre los productos de oxidación de colesterol (COPs) formados por autooxidación y factores de riesgo cardiovascular
Autor(es) : Menendez-Carreño, M. (María)
Varo, N. (Nerea)
Mugueta, C. (Carmen)
Restituto, P. (Patricia)
Ansorena, D. (Diana)
Astiasarán, I. (Iciar)
Palabras clave : Oxidation
Hypertriglyceridemia
Hypertension
Daibetes
Obesity
Atherosclerosis
Fecha incorporación: 2011
Editorial : Sociedad Española de Nutrición Parenteral y Enteral
Versión del editor: http://dx.doi.org/10.3305/nh.2011.26.1.4690
ISSN: 0212-1611
Cita: Menendez-Carreno M, Varo N, Mugueta C, Restituto P, Ansorena D, Astiasaran I. Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors. Nutr Hosp. 2011 Jan-Feb;26(1):144-51.
Resumen
BACKGROUND/AIMS: Risk factors for cardiovascular disease (CVD) have been proven to be associated with an increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as specific in vivo markers of oxidative stress. The aim of this study was to investigate the association between the levels of COPs derived from autoxidation processes and established cardiovascular risk factors, comparing the levels of serum COPs in subjects with or without showing values out of the reference ranges. METHODS: It was a cross-sectional study in which 88 subjects were recruited and individual and total COPs from autoxidation origin was analyzed in serum by GC-MS. The simultaneous correlation of COPs with different CVD risk factors have been analyzed. RESULTS AND DISCUSSION: A great variability of total COPs concentrations were found. Subjects presented total COPs values from 0.091 to 2.052 μg/mL. Total COPs were significantly higher (p < 0.05) in patients with hypertriglycerolemia, hypertension, diabetes and overweight/ obesity status compared to those subjects who did not present those CVD risk factors. Moreover, 7α and 7β hydroxycholesterol and 7-ketocholesterol were significantly higher (p < 0.05) in patients with hypertension and diabetes. No significant differences in total COPs were found between patients with and without hypercholesterolemia. CONCLUSIONS: The obtained results showed that the analyzed COPs correlate well with at least 4 out of 6 risk factors of development of CVD.
Enlace permanente: http://hdl.handle.net/10171/21335
Aparece en las colecciones: DA - Farmacia - CAFT - Artículos de revista

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