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|Long-term cardiac rehabilitation program favorably influences fibrinolysis and lipid concentrations in acute myocardial infarction|
|Authors: ||Paramo, J.A. (José Antonio)|
Olavide, I. (Isidro)
Barba, J. (Joaquín)
Montes, R. (Ramón)
Panizo, C. (Carlos)
Muñoz, M.C. (María Carmen)
Rocha, E. (Eduardo)
Acute myocardial infarction
|Issue Date: ||1998|
|Publisher: ||Ferrata Storti Foundation|
|Publisher version: ||http://www.haematologica.org/content/83/6/519|
|Citation: ||Paramo JA, Olavide I, Barba J, Montes R, Panizo C, Munoz MC, et al. Long-term cardiac rehabilitation program favorably influences fibrinolysis and lipid concentrations in acute myocardial infarction. Haematologica 1998 Jun;83(6):519-524.|
BACKGROUND AND OBJECTIVE: The control of well-known atherosclerotic risk factors represents the optimal strategy in the prevention of acute coronary syndromes. It was the aim of this work to analyze the effects of a long-term cardiac rehabilitation program on the changes of fibrinolysis parameters and plasma lipid profile in coronary patients.
DESIGN AND METHODS: The study was carried out in 30 (M/F:22/8, mean age 47 years) survivors of a first acute myocardial infarction (AMI) and in 30 healthy controls who underwent a cardiac rehabilitation program (9 months duration). Samples were taken before, at 3 and 9 months after the beginning of the program to measure: tissue-type plasminogen activator (t-PA) antigen and plasminogen activator inhibitor (PAI-1) activity and antigen. A lipid profile including cholesterol (both HDL and LDL) and lipoprotein(a) was also assessed. The Wilcoxon and Mann-Whitney tests were used for statistical comparisons.
RESULTS: There was a marked decrease of functional PAI-1 after 3 and 9 months as compared with baseline in AMI patients (p < 0.01). Results showed a significant increase of HDL-cholesterol (p < 0.01) and decrease of lipoprotein(a) levels after the exercise program (p < 0.01).
INTERPRETATION AND CONCLUSIONS: The cardiac rehabilitation program improved fibrinolysis, by reducing the functional levels of PAI-1, and ameliorated the lipid profile by decreasing lipoprotein(a) and increasing HDL-cholesterol in patients with AMI. A long-term cardiac rehabilitation has positive effects on some risk factors for coronary disease.
|Permanent link: ||http://hdl.handle.net/10171/22332|
|Appears in Collections:||DA - CIMA - Cardiovasculares - Trombosis y Hemostasia - Artículos de Revista|
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista
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