Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Sangro, B. (Bruno) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Quiroga, J. (Jorge) | - |
dc.creator | Rifon, J. J. (Jose J.) | - |
dc.creator | Rocha, E. (Eduardo) | - |
dc.date.accessioned | 2012-07-03T17:51:35Z | - |
dc.date.available | 2012-07-03T17:51:35Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Paramo JA, Sangro B, Prosper F, Quiroga J, Rifon J, Rocha E. Increased concentrations of tumor necrosis factor and interleukin-6 contribute to the hemostatic abnormalities in advanced liver disease. Haemostasis 1995 Nov-Dec;25(6):305-311. | es_ES |
dc.identifier.issn | 1423-0038 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22806 | - |
dc.description.abstract | Abnormal cytokine levels have been described in patients with chronic liver disease, but studies correlating cytokine homeostasis with abnormalities in coagulation and fibrinolysis are lacking. In order to establish a link between cytokines and the hemostatic changes the following parameters were determined in 44 patients with cirrhosis (alcoholic = 15, postnecrotic = 22, others = 7): TNF-alpha, IL-6, thrombin-antithrombin (TAT) complexes, prothrombin fragment 1 + 2 (F1 + 2) and t-PA by using enzyme-linked immunosorbent assays, and PAI-1, plasminogen and alpha 2-antiplasmin (alpha 2-AP) by using chromogenic substrates. All patients were at stages B and C of Child's classification when entering the study. Mean cytokine concentrations were significantly higher in cirrhotic patients as compared to age- and sex-matched controls (p < 0.009). There was a significant increase of TAT (p < 0.02) and F1 + 2 (p < 0.001) in the patients groups, suggesting a grade of intravascular coagulation. A hyperfibrinolytic state as demonstrated by an increase of t-PA and decrease of plasminogen and alpha 2-AP was also observed (p < 0.001). We could define a subgroup of patients with cytokine values higher than 20 pg/ml. Interestingly, in this group there was a significant increase of TAT (p < 0.04) and t-PA (p < 0.02) levels and a decrease of plasminogen and alpha 2-AP (p < 0.02) as compared to values observed in patients with cytokines lower than 20 pg/ml. We conclude that high levels of TNF-alpha and IL-6 may contribute to hyperfibrinolysis and intravascular coagulation in patients with liver cirrhosis, as assessed by the increase of TAT and t-PA levels and the reduction of plasminogen and alpha 2-AP. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Karger | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Liver disease | es_ES |
dc.subject | Tumor necrosis factor | es_ES |
dc.subject | Interleukin-6 | es_ES |
dc.subject | Thrombin-antithormbin complexes | es_ES |
dc.subject | Prothrombin fragment 1+2 | es_ES |
dc.subject | Disseminated intravascular coagulation | es_ES |
dc.subject | Fibrinolysis | es_ES |
dc.title | Increased concentrations of tumor necrosis factor and interleukin-6 contribute to the hemostatic abnormalities in advanced liver disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://bit.ly/Ly1wTE | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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