Antiphospholipid syndrome Thrombosis Fetal death Lupus anticoagulant
Ediciones Universidad de Navarra
Paramo JA, Garcia R, Rodriguez P, Panizo E, Lecumberri R. Tratamiento del síndrome antifosfolípido. Rev Med Univ Navarra 2007 Oct-Dec;51(4):38-41.
The antiphospholipid syndrome (APS) is a disorder of recurrent thrombosis and/or pregnancy loss associated with the presence of antiphospholipid antibodies and persistently positive lupus anticoagulant, anticardiolipin or anti beta2-glycoprotein1. Oral anticoagulants are the best available and most effective treatment for the secondary prevention of recurrent venous or arterial thrombosis. Patients with APS are treated with long-term therapy to prolong the INR to 2.0-3.0. Low-molecular-weight heparin in combination with low-aspirin dose is a reasonable strategy to avoid pregnancy loss in women with this syndrome.