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dc.creatorParamo, J.A. (José Antonio)-
dc.creatorBeloqui, O. (Óscar)-
dc.creatorRoncal, C. (Carmen)-
dc.creatorBenito, A. (Alberto)-
dc.creatorOrbe, J. (Josune)-
dc.date.accessioned2012-07-11T16:31:42Z-
dc.date.available2012-07-11T16:31:42Z-
dc.date.issued2004-
dc.identifier.citationParamo JA, Beloqui O, Roncal C, Benito A, Orbe J. Validation of plasma fibrinogen as a marker of carotid atherosclerosis in subjects free of clinical cardiovascular disease. Haematologica 2004 Oct;89(10):1226-1231.es_ES
dc.identifier.issn1592-8721-
dc.identifier.urihttp://hdl.handle.net/10171/22868-
dc.description.abstractBACKGROUND AND OBJECTIVES: Fibrinogen has been found to be an independent risk factor for cardiovascular disease. The aim of this study was to validate the measurement of plasma fibrinogen as a marker of subclinical atherosclerosis in a series of asymptomatic subjects (n=519, median age 55.5 years, 80% men). DESIGN AND METHODS: All individuals had a complete clinical examination, lipid profile (cholesterol and its high and low density lipoprotein fractions and triglycerides), global vascular risk assessment (PROCAM), and B-mode ultrasonography of the carotid arteries to determine the intima-media thickness (IMT) and the presence of atheroma plaques. C-reactive protein (CRP), and von Willebrand factor (vWF) were also measured in all subjects as markers of inflammation/endothelial damage. RESULTS: In the univariate model, a positive relationship was found between plasma fibrinogen concentration and carotid IMT (p<0.001). Fibrinogen concentration also correlated positively with age (p<0.001), systolic blood pressure (p<0.001), smoking (p<0.05), diabetes (p<0.05), PROCAM (p<0.001), CRP and vWF (p<0.001). In the multivariate analysis, the association of fibrinogen with carotid IMT remained significant (p=0.008) after adjustment for all parameters analyzed. INTERPRETATION AND CONCLUSIONS: In a population sample of adults without clinically overt atherosclerotic disease, elevated fibrinogen levels was related to carotid IMT independently of a wide range of important confounding variables. Plasma fibrinogen may represent a systemic marker of carotid atherosclerosis.es_ES
dc.language.isoenges_ES
dc.publisherFerrata Storti Foundationes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectFibrinogenes_ES
dc.subjectInflammationes_ES
dc.subjectAtherosclerosises_ES
dc.subjectCarotid intima-media thicknesses_ES
dc.titleValidation of plasma fibrinogen as a marker of carotid atherosclerosis in subjects free of clinical cardiovascular diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.haematologica.org/content/89/10/1226es_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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