Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | Zulet, M.A. (María Ángeles) | - |
dc.creator | O'Gorman, A. (A.) | - |
dc.creator | Hermsdorff, H.H. (H. H.) | - |
dc.creator | Ibero-Baraibar, I. (Idoia) | - |
dc.creator | Brennan, L. (Lorraine) | - |
dc.creator | Perez-Cornago, A. (Aurora) | - |
dc.date.accessioned | 2014-05-15T09:22:11Z | - |
dc.date.available | 2014-05-15T09:22:11Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Pérez-Cornago A, Brennan L, Ibero-Baraibar I, Hermsdorff HHM, O'Gorman A, Zulet MA, et al. Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention. J Physiol Biochem 2014 Jun;70(2):593-602 | es_ES |
dc.identifier.issn | 1877-8755 | - |
dc.identifier.uri | https://hdl.handle.net/10171/35863 | - |
dc.description.abstract | The application of metabolomics in nutritional research may be a useful tool to analyse and predict the response to a dietary intervention. The aim of this study was to examine metabolic changes in serum samples following exposure to an energy-restricted diet (-15% of daily energy requirements) over a period of 8weeks in overweight and obese older adults (n=22) using a gas chromatography/mass spectrometry (GC/MS) metabolomic approach. After 8weeks, there were significant reductions in weight (7%) and metabolic improvement (glucose and lipid profiles). Metabolomic analysis found that total saturated fatty acids (SFAs), including palmitic acid (C16:0) and stearic acid (C18:0) and monounsaturated fatty acids (MUFAs), were significantly decreased after the 8-week intervention. Furthermore, palmitoleic acid (C16:1) was found to be a negative predictor of change in body fat loss. Both the total omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) significantly decreased, although the overall total amounts of PUFAs did not. The branched chain amino acid (BCAA) isoleucine significantly decreased in the serum samples after the intervention. In conclusion, this study demonstrated that the weight loss intervention based on a hypocaloric diet identified changes in the metabolic profiles of serum in overweight and obese older adults, with a reduction in anthropometric and biochemical parameters also found. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Older adults | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Weight loss | es_ES |
dc.subject | Amino acids | es_ES |
dc.subject | Fatty acids | es_ES |
dc.subject | Metabolomics | es_ES |
dc.title | Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1007/s13105-013-0311-2 | es_ES |
Ficheros en este ítem:
Estadísticas e impacto
Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.