Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia
Keywords: 
VEGF
CoQ10
Protein delivery
Angiogenesis
Tissue engineering
Myocardial ischemia
Issue Date: 
2013
Publisher: 
Elsevier
ISSN: 
0378-5173
Citation: 
Simón-Yarza T, Tamayo E, Benavides C, Lana H, Formiga FR, Grama CR, et al. Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia. Int J Pharm 2013 Oct 1;454(2):784-790
Abstract
Myocardial ischemia (MI) remains one of the leading causes of death worldwide. Angiogenic therapy with the vascular endothelial growth factor (VEGF) is a promising strategy to overcome hypoxia and its consequences. However, from the clinical data it is clear that fulfillment of the potential of VEGF warrants a better delivery strategy. On the other hand, the compelling evidences of the role of oxidative stress in diseases like MI encourage the use of antioxidant agents. Coenzyme Q10 (CoQ10) due to its role in the electron transport chain in the mitochondria seems to be a good candidate to manage MI but is associated with poor biopharmaceutical properties seeking better delivery approaches. The female Sprague Dawley rats were induced MI and were followed up with VEGF microparticles intramyocardially and CoQ10 nanoparticles orally or their combination with appropriate controls. Cardiac function was assessed by measuring ejection fraction before and after three months of therapy. Results demonstrate significant improvement in the ejection fraction after three months with both treatment forms individually; however the combination therapy failed to offer any synergism. In conclusion, VEGF microparticles and CoQ10 nanoparticles can be considered as promising strategies for managing MI.

Files in This Item:
File: 
Manuscriopt-IJP-D-13-00239-R1.pdf
Description: 
Size: 
148,94 kB
Format: 
Adobe PDF
File: 
Figure 1-R1.pdf
Description: 
Size: 
32,46 kB
Format: 
Adobe PDF
File: 
Figure2.pdf
Description: 
Size: 
58,6 kB
Format: 
Adobe PDF
File: 
Figure3.pdf
Description: 
Size: 
170,73 kB
Format: 
Adobe PDF
File: 
Figure4.pdf
Description: 
Size: 
236,29 kB
Format: 
Adobe PDF
File: 
graphical abstract-1.pdf
Description: 
Size: 
61,57 kB
Format: 
Adobe PDF
File: 
Simon-Yarza et al-Table1.pdf
Description: 
Size: 
20,17 kB
Format: 
Adobe PDF
File: 
Table1.pdf
Description: 
Size: 
99,63 kB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.