Full metadata record
DC Field | Value | Language |
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dc.creator | Crujeiras, A.B. (Ana B.) | - |
dc.creator | Parra, M.D. (M. D.) | - |
dc.creator | Milagro-Yoldi, F.I. (Fermín Ignacio) | - |
dc.creator | Goyenechea, E. (Estíbaliz) | - |
dc.creator | Larrarte, E. (Eider) | - |
dc.creator | Margareto, J. (Javier) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.date.accessioned | 2015-02-23T16:42:07Z | - |
dc.date.available | 2015-02-23T16:42:07Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Crujeiras AB, Parra D, Milagro FI, Goyenechea E, Larrarte E, Margareto J, et al. Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study. OMICS. Dec 2008;12(4):251-261 | es_ES |
dc.identifier.issn | 1536-2310 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37637 | - |
dc.description.abstract | Nutrigenomics is a new application of omics technologies in nutritional science. Nutrigenomics aims to identify molecular markers of diet-related diseases and mechanisms of interindividual variability in response to food. The aim of this study was to evaluate peripheral blood mononuclear cells (PBMC) as a model system and readily available source of RNA to discern gene expression signatures in relation to personalized therapy of obesity. PBMC were collected from obese men before and after an 8-week low-calorie diet (LCD) to lose weight. Changes in gene expression before and after the LCD were initially screened using a DNA-microarray platform and validated by qRT-PCR. Global gene expression analysis identified 385 differentially expressed transcripts after the LCD. Further analyses showed a decrease in some specific oxidative stress and inflammation genes. Interestingly, expression of these genes was directly related to body weight, while a lower IL8 gene expression was associated with higher fat mass decrease. Collectively, these observations suggest that PBMCs are a suitable RNA source and model system to perform nutrigenomics studies related to obesity and development of personalized dietary treatments. IL8 gene expression warrant further research as a putative novel biomarker of changes in body fat percentage in response to an LCD. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Mary Ann Liebert | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Blood pressure | es_ES |
dc.subject | Gene expression | es_ES |
dc.subject | Transcriptomics | es_ES |
dc.subject | Adipocytes | es_ES |
dc.title | Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1089/omi.2008.0001 | es_ES |
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