Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Crozier, A. (Alan) | - |
dc.creator | Cid, C. (Concepción) | - |
dc.creator | Peña, M.P. (María Paz) de | - |
dc.creator | Stalmach, A. (Angelique) | - |
dc.creator | Ludwig, I.A. (Iziar Amaia) | - |
dc.creator | Monente, C. (Carmen) | - |
dc.date.accessioned | 2016-03-01T13:20:13Z | - |
dc.date.available | 2016-03-01T13:20:13Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Monente C, Ludwig IA, Stalmach A, de Peña MP, Cid C, Crozier A. In vitro studies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds. Int J Food Sci Nutr. 2015;66(6):657-664 | es_ES |
dc.identifier.issn | 0963-7486 | - |
dc.identifier.uri | https://hdl.handle.net/10171/40094 | - |
dc.description.abstract | Spent coffee grounds are a potential commercial source of substantial amounts of chlorogenic acids (CGAs). The aim of this study was to evaluate the stability of spent coffee CGAs using in vitro simulated gastroduodenal digestion and to investigate their potential absorption using an in vitro Caco-2 model of human small intestinal epithelium. During in vitro digestion, lactones were partially degraded while caffeoylquinic and feruloylquinic acids were much more stable. Transport and metabolism studies showed that 1% of the total CGAs were absorbed and transported from the apical to the basolateral side of a Caco-2 cell monolayer after 1 h. Lactones and coumaroylquinic acids showed the rate of highest absorption. Caco-2 cells possessed low metabolic activity. In conclusion, spent coffee extracts contain large amounts of CGAs, which remained bioaccessible across the intestinal barrier, albeit to a relatively low degree. | es_ES |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness (AGL2009-12052) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Taylor & Francis | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | * |
dc.subject | Spent coffee grounds | es_ES |
dc.subject | In vitro gastrointestinal stability | es_ES |
dc.subject | In vitro bioaccessibility | es_ES |
dc.subject | Chlorogenic acids | es_ES |
dc.title | In vitro studies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.editorial.note | This is an Accepted Manuscript of an article published by Taylor & Francis in Int J Food Sci Nutr on 23 Jul 2015, available online: http://wwww.tandfonline.com/10.3109/09637486.2015.1064874 | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3109/09637486.2015.1064874 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.