Full metadata record
DC Field | Value | Language |
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dc.creator | Ros, E. (Emilio) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.creator | Fit, M. (Montserrat) | - |
dc.creator | Corella, D. (Dolores) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | Serra-Majem, L. (Luis) | - |
dc.creator | Muñoz, M.A. (Miguel Angel) | - |
dc.creator | Fiol, M. (Miquel) | - |
dc.creator | Aros, F. (Fernando) | - |
dc.creator | Sorli, J.V. (Jose V.) | - |
dc.creator | Lopez-Sabater, M.C. (M. Carmen) | - |
dc.creator | Serra-Mir, M. (Merce) | - |
dc.creator | Bullo, M. (Monica) | - |
dc.creator | Sanchez-Tainta, A. (Ana) | - |
dc.creator | Hu, F.B. (Frank B.) | - |
dc.creator | Guasch-Ferre, M. (Marta) | - |
dc.creator | Sala-Vila, A. (Aleix) | - |
dc.date.accessioned | 2016-10-18T09:21:01Z | - |
dc.date.available | 2016-10-18T09:21:01Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Sala-Vila A, Guasch-Ferr M, Hu FB, Sanchez-Tainta A, Bullo M, Serra-Mir M, et al. Dietary a-Linolenic Acid, Marine x-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study. J Am Heart Assoc. 2016 Jan 26;5(1): e002543. | es_ES |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://hdl.handle.net/10171/41853 | - |
dc.description.abstract | Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine x-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society’s recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results-—We longitudinally evaluated 7202 participants in the PREvenci on con DIeta MEDiterr anea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56–0.92) for all-causemortality and 0.95 (95% CI 0.58–1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67–1.05) for all-causemortality, 0.61 (95% CI 0.39–0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29–0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22–1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45–0.87]). Conclusions-—In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids. | es_ES |
dc.description.sponsorship | This study was funded in part by Instituto de Salud Carlos III (ISCIII) (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/ 01292, the Spanish Ministry of Science and Innovation (MICINN) AGL2010-22319-C03-02 and AGL2009-13906-C02- 02, and an unrestricted grant from the California Walnut Commission. Sala-Vila holds a Miguel Servet I fellowship from the Ministry of Economy and Competitiveness through the ISCIII. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Heart Association | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Medicina preventiva | es_ES |
dc.subject | Sudden cardiac death | es_ES |
dc.subject | Nutrition | es_ES |
dc.subject | Fatty acid | es_ES |
dc.title | Dietary a-Linolenic acid, Marine x-3 fatty acids, and mortality in a population with high fish consumption: findings from the PREevención con DIeta MEDiterránea (PREDIMED) study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.editorial.note | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1161/JAHA.115.002543 | es_ES |
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