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dc.creatorGayoso, L. (Lucía)-
dc.creatorRoxo, M. (Mariana)-
dc.creatorCavero, R.Y. (Rita Yolanda)-
dc.creatorCalvo, M.I. (María Isabel)-
dc.creatorAnsorena, D. (Diana)-
dc.creatorAstiasaran, I. (Iciar)-
dc.creatorWink, M. (Michael)-
dc.date.accessioned2019-01-10T09:13:13Z-
dc.date.available2019-01-10T09:13:13Z-
dc.date.issued2018-
dc.identifier.citationGayoso, L. (Lucía); Roxo, M. (Mariana); Cavero, R.Y. (Rita Yolanda); et al. "Bioaccessibility and biological activity of Melissa officinalis, Lavandula latifolia and Origanum vulgare extracts: influence of an in vitro gastrointestinal digestion". . 44, 2018, 146 - 154es
dc.identifier.issn1756-4646-
dc.identifier.urihttp://hdl.handle.net/10171/56192-
dc.description.abstractMelissa officinalis, Lavandula latifolia and Origanum vulgare are widely used medicinal plants and spices. Their extracts were evaluated as potential antioxidants for functional food formulations. After being submitted to an in vitro gastrointestinal digestion, all the extracts showed antioxidant activity (measured by DPPH, ABTS, FRAP, TPC). Furthermore, their main polyphenols maintained high stability. Biological activity was measured using Caenorhabditis elegans, which is a widely used model in this context. Treatments of 50 and 100 µg/mL of M. officinalis significantly attenuated juglone-induced stress in the survival assay performed; moreover, all tested concentrations decreased intracellular ROS. Lavandula latifolia and O. vulgare had no significant effect against acute stress in the survival assay, but significantly decreased ROS basal levels. GST-4 expression under juglone-induced oxidative stress was significantly down-regulated by treatment with the three plant extracts (up to 63%). Besides, similar biological activity of all digested extracts was demonstrated in all in vivo assays.es_ES
dc.description.sponsorshipWe thank the Ministerio de Economía y Competitividad- Spain (AGL2014-52636-P) for the financial support. L. Gayoso is supported by a pre-doctoral fellowship from Gobierno de Navarra (Departamento de Educación). Fundación Bancaria La Caixa is also acknowledged for the mobility fellowship to L. Gayoso.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_ES
dc.subjectPolyphenolses_ES
dc.subjectCaenorhabditis eleganses_ES
dc.subjectAntioxidantses_ES
dc.subjectLemon balmes_ES
dc.subjectOreganoes_ES
dc.subjectLavenderes_ES
dc.subjectPlant extractes_ES
dc.titleBioaccessibility and biological activity of Melissa officinalis, Lavandula latifolia and Origanum vulgare extracts: influence of an in vitro gastrointestinal digestiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jff.2018.03.003es_ES
dc.identifier.doi10.1016/j.jff.2018.03.003-

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