Full metadata record
DC Field | Value | Language |
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dc.creator | Canudas, Silvia (S.) | - |
dc.creator | Hernandez-Alonso, P. (Pablo) | - |
dc.creator | Galié, S. (Serena) | - |
dc.creator | Muralidharan, J. (Jananee) | - |
dc.creator | Morell-Azanza, L. (Lydia) | - |
dc.creator | Zalba, G. (Guillermo) | - |
dc.creator | García-Gavilán, J.F. (Jesús F.) | - |
dc.creator | Marti-del-Moral, A. (Amelia) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.creator | Bullo, M. (Monica) | - |
dc.date.accessioned | 2021-09-24T07:32:34Z | - |
dc.date.available | 2021-09-24T07:32:34Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Canudas, S. (S.); Hernandez-Alonso, P. (Pablo); Galié, S. (Serena); et al. "Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial". The American Journal of Clinical Nutrition. 109, 2019, 1738 - 1745 | es_ES |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.other | PMID: 31051499 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62065 | - |
dc.description.abstract | Background: Telomere attrition may play an important role in the pathogenesis and severity of type 2 diabetes (T2D), increasing the probability of β cell senescence and leading to reduced cell mass and decreased insulin secretion. Nutrition and lifestyle are known factors modulating the aging process and insulin resistance/secretion, determining the risk of T2D. Objectives: The aim of this study was to evaluate the effects of pistachio intake on telomere length and other cellular aging-related parameters of glucose and insulin metabolism. Methods: Forty-nine prediabetic subjects were included in a randomized crossover clinical trial. Subjects consumed a pistachio-supplemented diet (PD, 50 E% [energy percentage] carbohydrates and 33 E% fat, including 57 g pistachios/d) and an isocaloric control diet (CD, 55 E% carbohydrates and 30 E% fat) for 4 mo each, separated by a 2-wk washout period. DNA oxidation was evaluated by DNA damage (via 8-hydroxydeoxyguanosine). Leucocyte telomere length and gene expression related to either oxidation, telomere maintenance or glucose, and insulin metabolism were analyzed by multiplexed quantitative reverse transcriptase-polymerase chain reaction after the dietary intervention. Results: Compared with the CD, the PD reduced oxidative damage to DNA (mean: -3.5%; 95% CI: -8.07%, 1.05%; P = 0.009). Gene expression of 2 telomere-related genes (TERT and WRAP53) was significantly upregulated (164% and 53%) after the PD compared with the CD (P = 0.043 and P = 0.001, respectively). Interestingly, changes in TERT expression were negatively correlated to changes in fasting plasma glucose concentrations and in the homeostatic model assessment of insulin resistance. Conclusions: Chronic pistachio consumption reduces oxidative damage to DNA and increases the gene expression of some telomere-associated genes. Lessening oxidative damage to DNA and telomerase expression through diet may represent an intriguing way to promote healthspan in humans, reversing certain deleterious metabolic consequences of prediabetes. | es_ES |
dc.description.sponsorship | The Western Pistachio Association (USA) and Paramount Farms supported the trial. SC was supported by a Ramon y Cajal contract (RYC-2013-12598) funded by the Spanish Ministry of Science, Innovation and Universities, with additional funding supporting this study; SG was supported by a predoctoral fellowship from AGAUR (2018FI_B_00444); JM received funding from the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement 713679 and from the Universitat Rovira i Virgili (URV); JG was awarded a predoctoral grant (PFIS FI17/00255) from the Instituto de Salud Carlos III (ISCIII); and LMA received her fellowship from the “La Caixa” Foundation. The study was funded by the Spanish Ministry of Science, Innovation and Universities (RYC-2013-12598), the Navarra Government (PI 54/2009), PIUNA, and CIBERobn (project CIBER, CB06/03). CIBERobn is an initiative of the ISCIII, Spain, which is supported by FEDER funds (CB06/03). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press (OUP) | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/713679/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Nutrición y dietética | es_ES |
dc.title | Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.identifier.doi | 10.1093/ajcn/nqz048 | - |
dadun.citation.endingPage | 1745 | es_ES |
dadun.citation.publicationName | The American Journal of Clinical Nutrition | es_ES |
dadun.citation.startingPage | 1738 | es_ES |
dadun.citation.volume | 109 | es_ES |
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