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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Lopez-Pascual, A. (Amaya) | - |
dc.creator | Urrutia-Sarratea, A. (Andoni) | - |
dc.creator | Lorente-Cebrian, S. (Silvia) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | Gonzalez-Muniesa, P. (Pedro) | - |
dc.date.accessioned | 2022-03-11T13:49:35Z | - |
dc.date.available | 2022-03-11T13:49:35Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Lopez-Pascual, A. (Amaya); Urrutia-Sarratea, A. (Andoni); Lorente-Cebrian, S. (Silvia); et al. "Cerium oxide nanoparticles regulate insulin sensitivity and oxidative markers in 3T3-L1 adipocytes and C2C12 myotubes". Oxidative Medicine and Cellular Longevity. 2019, 2019, 2695289 | es |
dc.identifier.issn | 1942-0994 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63160 | - |
dc.description.abstract | Insulin resistance is associated with oxidative stress, mitochondrial dysfunction, and a chronic low-grade inflammatory status. In this sense, cerium oxide nanoparticles (CeO2 NPs) are promising nanomaterials with antioxidant and anti-inflammatory properties. Thus, we aimed to evaluate the effect of CeO2 NPs in mouse 3T3-L1 adipocytes, RAW 264.7 macrophages, and C2C12 myotubes under control or proinflammatory conditions. Macrophages were treated with LPS, and both adipocytes and myotubes with conditioned medium (25% LPS-activated macrophages medium) to promote inflammation. CeO2 NPs showed a mean size of ≤25.3 nm (96.7%) and a zeta potential of mV, suitable for cell internalization. CeO2 NPs reduced extracellular reactive oxygen species (ROS) in adipocytes with inflammation while increased in myotubes with control medium. The CeO2 NPs increased mitochondrial content was observed in adipocytes under proinflammatory conditions. Furthermore, the expression of Adipoq and Il10 increased in adipocytes treated with CeO2 NPs. In myotubes, both Il1b and Adipoq were downregulated while Irs1 was upregulated. Overall, our results suggest that CeO2 NPs could potentially have an insulin-sensitizing effect specifically on adipose tissue and skeletal muscle. However, further research is needed to confirm these findings. | es_ES |
dc.description.sponsorship | This project has received funding from the Spanish Government Carlos III Health Institute Centre of Biomedical Research Network: CIBERobn Physiopathology of Obesity and Nutrition (CB1 2/03/30002) and the University of Navarra. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Hindawi Limited | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Insulin resistance | es_ES |
dc.subject | Cerium oxide nanoparticles | es_ES |
dc.subject | CeO2 | es_ES |
dc.title | Cerium oxide nanoparticles regulate insulin sensitivity and oxidative markers in 3T3-L1 adipocytes and C2C12 myotubes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.identifier.doi | 10.1155/2019/2695289 | - |
dadun.citation.publicationName | Oxidative Medicine and Cellular Longevity | es_ES |
dadun.citation.startingPage | 2695289 | es_ES |
dadun.citation.volume | 2019 | es_ES |
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