Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Cantero-González, I. (Irene) | - |
dc.creator | Elorz, M. (Mariana) | - |
dc.creator | Abete, I. (Itziar) | - |
dc.creator | Marin-Alejandre, B.A. (Bertha Araceli) | - |
dc.creator | Herrero, J.I. (José Ignacio) | - |
dc.creator | Monreal, J.I. (José Ignacio) | - |
dc.creator | Benito-Boilos, A. (Alberto) | - |
dc.creator | Quiroga, J. (Jorge) | - |
dc.creator | Martínez, A. (Ana) | - |
dc.creator | Huarte-Muniesa, M.P. (Maria Pilar) | - |
dc.creator | Uriz-Otano, J.I. (Juan Isidoro) | - |
dc.creator | Tur, J.A. (Josep A.) | - |
dc.creator | Kearney, J. (J.) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.creator | Zulet, M.A. (María Ángeles) | - |
dc.date.accessioned | 2022-06-28T09:49:57Z | - |
dc.date.available | 2022-06-28T09:49:57Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Cantero-González, I. (Irene); Elorz, M. (M.); Abete, I. (Itziar); et al. "Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults". International Journal of Medical Sciences. 16 (1), 2019, 75 - 83 | es |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | 10.7150/ijms.28044 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63708 | - |
dc.description.abstract | Introduction: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations. Objective: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease. Materials and methods: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Body composition (DXA), hepatic related biochemical measurements as well as the Fatty Liver Index (FLI) were evaluated. This study was registered as FLiO: Fatty Liver in Obesity study; NCT03183193. Results: The subjects with more severe liver disease were found to have worse metabolic parameters. Positive associations between MRI with inflammatory and insulin biomarkers were found. A linear regression model including ALT, RBP4 and HOMA-IR was able to explain 40.9% of the variability in fat content by MRI. In ROC analyses a combination panel formed of ALT, HOMA-IR and RBP4 followed by ultrasonography, ALT and metabolomic test showed the major predictive ability (77.3%, 74.6%, 74.3% and 71.1%, respectively) for liver fat content. Conclusions: A panel combination including routine blood markers linked to insulin resistance showed highest associations with MRI considered as a gold standard for determining liver fat content. This combination of tests can facilitate the diagnosis of early stages of non-alcoholic liver disease thereby avoiding other invasive and expensive methods. | es_ES |
dc.description.sponsorship | Health Department of the Government of Navarra (61/2015), CIBERobn (Physiopathology of Obesity and Nutrition) and to Fundació La Marató de TV3 (201630.10). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ivyspring International Publisher | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Non-alcoholic fatty liver disease (NAFLD) | es_ES |
dc.subject | Steatohepatitis | es_ES |
dc.subject | Cirrhosis | es_ES |
dc.subject | Hepatocellular carcinoma | es_ES |
dc.title | Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. | es_ES |
dadun.citation.endingPage | 83 | es_ES |
dadun.citation.number | 1 | es_ES |
dadun.citation.publicationName | International Journal of Medical Sciences | es_ES |
dadun.citation.startingPage | 75 | es_ES |
dadun.citation.volume | 16 | es_ES |
Ficheros en este ítem:
Estadísticas e impacto
Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.