Full metadata record
DC Field | Value | Language |
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dc.creator | Jönsson, J. (Josefine) | - |
dc.creator | Renault, K.M. (Kristina M.) | - |
dc.creator | Garcia-Calzon, S. (Sonia) | - |
dc.creator | Perfilyev, A. (Alexander) | - |
dc.creator | Estampador, A.C. (Ángela C.) | - |
dc.creator | Nørgaard, K. (Kirsten) | - |
dc.creator | Vendelbo-Lind, M. (Mads) | - |
dc.creator | Vaag, A. (Allan) | - |
dc.creator | Hjort, L. (Line) | - |
dc.creator | Michaelsen, K.F. (Kim F.) | - |
dc.creator | Carlsen, E.M. (Emma Malchau) | - |
dc.creator | Franks, P.W. (Paul W.) | - |
dc.creator | Ling, C. (Charlotte) | - |
dc.date.accessioned | 2024-01-24T12:52:01Z | - |
dc.date.available | 2024-01-24T12:52:01Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Jönsson, J. (Josefine); Renault, K.M. (Kristina M.); Garcia-Calzon, S. (Sonia); et al. "Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring". Diabetes. 70 (4), 2021, 854 - 866 | es |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://hdl.handle.net/10171/68509 | - |
dc.description.abstract | Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic variation in cord blood and body composition in the offspring. Genome-wide DNA methylation was analyzed in cord blood from 208 offspring from the Treatment of Obese Pregnant women (TOP)-study, which includes pregnant women with obesity randomized to lifestyle interventions comprised of physical activity with or without dietary advice versus control subjects (standard of care). DNA methylation was altered at 379 sites, annotated to 370 genes, in cord blood from offspring of mothers following a lifestyle intervention versus control subjects (false discovery rate [FDR] <5%) when using the Houseman reference-free method to correct for cell composition, and three of these sites were significant based on Bonferroni correction. These 370 genes are overrepresented in gene ontology terms, including response to fatty acids and adipose tissue development. Offspring of mothers included in a lifestyle intervention were born with more lean mass compared with control subjects. Methylation at 17 sites, annotated to, for example, DISC1, GBX2, HERC2, and HUWE1, partially mediates the effect of the lifestyle intervention on lean mass in the offspring (FDR <5%). Moreover, 22 methylation sites were associated with offspring BMI z scores during the first 3 years of life (P < 0.05). Overall, lifestyle interventions in pregnant women with obesity are associated with epigenetic changes in offspring, potentially influencing the offspring's lean mass and early growth. | es_ES |
dc.description.sponsorship | Sygekassernes Helsefond, Hartmann Fonden, Hvidovre Hospital, and The Danish Council for Strategic Research supported the TOP-study. The work performed by A.C.E. and P.W.F. was supported by grants from the European Foundation for the Study of Diabetes, Vetenskapsrådet, Hjärt-Lungfonden, the H2020 European Research Council (CoG-2015_681742_NASCENT), and Novo Nordisk Fonden. The work performed by J.J., S.G.-C., A.P., and C.L. was supported by grants from the Novo Nordisk Fonden, Vetenskapsrådet, and Region Skåne (ALF), an H2020 European Research Council co-grant (PAINTBOX, number 725840), H2020 Marie Skłodowska-Curie Actions grant agreement 706081 (Epi- Hope), Hjärt-Lungfonden, EXODIAB, Stiftelsen för Strategisk Forskning (IRC15- 0067), and Diabetesförbundet. All researchers from Lund University Diabetes Centre were supported by a research center grant from the Swedish Strategic Science Foundation | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Diabetes Association | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/706081/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/681742/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/725840/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud | es_ES |
dc.subject | Lifestyle intervention | es_ES |
dc.subject | Pregnant women | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Offspring | es_ES |
dc.title | Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.2337/db20-0487 | - |
dadun.citation.endingPage | 866 | es_ES |
dadun.citation.number | 4 | es_ES |
dadun.citation.publicationName | Diabetes | es_ES |
dadun.citation.startingPage | 854 | es_ES |
dadun.citation.volume | 70 | es_ES |
dc.identifier.pmid | 33431374 | - |
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