Depósito Académico
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- Three-dimensional bioprinting scaffolding for nasal cartilage defects: A systematic review.(Springer, 2021) Garcés, J.P. (Juan P.); Chiesa-Estomba, C.M. (Carlos M.); Delgado, A. (Alba); Hernaez-Moya, R. (Raquel); Aldazabal, J. (Javier); Rodino, C. (Claudia); González-Fernández, I. (Iago); Altuna, X. (Xabier); Izeta, A. (Ander); Aiastui, A. (Ana); Paredes-Puente, J. (Jacobo)In recent years, three-dimensional (3D)-printing of tissue-engineered cartilaginous scaffolds is intended to close the surgical gap and provide bio-printed tissue designed to fit the specific geometric and functional requirements of each cartilage defect, avoiding donor site morbidity and offering a personalizing therapy. METHODS: To investigate the role of 3D-bioprinting scaffolding for nasal cartilage defects repair a systematic review of the electronic databases for 3D-Bioprinting articles pertaining to nasal cartilage bio-modelling was performed. The primary focus was to investigate cellular source, type of scaffold utilization, biochemical evaluation, histological analysis, in-vitro study, in-vivo study, animal model used, length of research, and placement of experimental construct and translational investigation. RESULTS: From 1011 publications, 16 studies were kept for analysis. About cellular sources described, most studies used primary chondrocyte cultures. The cartilage used for cell isolation was mostly nasal septum. The most common biomaterial used for scaffold creation was polycaprolactone alone or in combination. About mechanical evaluation, we found a high heterogeneity, making it difficult to extract any solid conclusion. Regarding biological and histological characteristics of each scaffold, we found that the expression of collagen type I, collagen Type II and other ECM components were the most common patterns evaluated through immunohistochemistry on in-vitro and in-vivo studies. Only two studies made an orthotopic placement of the scaffolds. However, in none of the studies analyzed, the scaffold was placed in a subperichondrial pocket to rigorously simulate the cartilage environment. In contrast, scaffolds were implanted in a subcutaneous plane in almost all of the studies included. CONCLUSION: The role of 3D-bioprinting scaffolding for nasal cartilage defects repair is growing field. Despite the amount of information collected in the last years and the first surgical applications described recently in humans. Further investigations are needed due to the heterogeneity on mechanical evaluation parameters, the high level of heterotopic scaffold implantation and the need for quantitative histological data.
- Contractile force assessment methods for in vitro skeletal muscle tissues.(eLIFE Sciences Publ. LTD., 2022) Vallejo-Illarramendi, A. (Ainara); Aldazabal, J. (Javier); Vesga-Castro, C. (Camila); Paredes-Puente, J. (Jacobo)Over the last few years, there has been growing interest in measuring the contractile force (CF) of engineered muscle tissues to evaluate their functionality. However, there are still no standards available for selecting the most suitable experimental platform, measuring system, culture protocol, or stimulation patterns. Consequently, the high variability of published data hinders any comparison between different studies. We have identified that cantilever deflection, post deflection, and force transducers are the most commonly used configurations for CF assessment in 2D and 3D models. Additionally, we have discussed the most relevant emerging technologies that would greatly complement CF evaluation with intracellular and localized analysis. This review provides a comprehensive analysis of the most significant advances in CF evaluation and its critical parameters. In order to compare contractile performance across experimental platforms, we have used the specific force (sF, kN/m2 ), CF normalized to the calculated cross-sectional area (CSA). However, this parameter presents a high variability throughout the different studies, which indicates the need to identify additional parameters and complementary analysis suitable for proper comparison. We propose that future contractility studies in skeletal muscle constructs report detailed information about construct size, contractile area, maturity level, sarcomere length, and, ideally, the tetanusto-twitch ratio. These studies will hopefully shed light on the relative impact of these variables on muscle force performance of engineered muscle constructs. Prospective advances in muscle tissue engineering, particularly in muscle disease models, will require a joint effort to develop standardized methodologies for assessing CF of engineered muscle tissues.
- Effectiveness of web-based personalised feedback interventions for reducing alcohol consumption among university students: A systematic review and meta-analysis(2024) Esandi, N. (Nuria); Carver, H. (Hannah); Pueyo-Garrigues, M. (María); Alfaro-Díaz, C. (Cristina); Parr, A. (Amy); Canga-Armayor, N. (Navidad); Lavilla-Gracia, M. (María)Meta-analysis was conducted to examine standalone web-based personalised feedback interventions (PFI) delivered in non-structured settings for reducing university students' alcohol consumption. Subgroup analyses by gender-focus, type-of-content and accessibility were conducted. Characteristics of the sample, the intervention and study quality were examined as moderators.ApproachTen databases were searched from 2000 to 2023. Eligible articles involved only randomised controlled trials. Random-effects meta-analysis was conducted to calculate the effect size on weekly alcohol consumption comparing web-PFIs and non-active controls. Meta-regressions were applied to explore effect moderators.Key FindingsThirty-one studies were included in the narrative synthesis, 25 of which were meta-analysed. Results found significant effect size differences on weekly alcohol consumption in favour of the intervention group in the short- (SMD = 0.11, 95% confidence interval [CI] 0.06, 0.15) and long-term period (SMD = 0.09, 95% CI 0.02, 0.15). Subgroup analyses identified that interventions which were gender-specific, multicomponent and had unlimited access had higher and significant effect sizes, although they were very similar with respect to comparative groups. Moderator analyses showed that times feedback was accessed significantly contributed to the effectiveness of the intervention. Effects diminished over time, although they remained significant.ImplicationsThe meta-analysis evidences the effectiveness of web-PFI for addressing university students' alcohol use, decreasing by 1.65 and 1.54 drinks consumed per week in the short- and long-term, respectively.ConclusionsThe results offer empirical evidence that supports the significant, although small, effect of web-PFI delivered remotely in universities. Future research should focus on increasing their impact by introducing booster sessions and content components based on students' preferences.
- Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review(2024) Pouwels, K.B. (Koen B.); Allel, K. (Kasim); Haghparast-Bidgoli, H. (Hassan); Flanagan, E. (Ellen); Abou-Jaoude, G.J. (Gerard Joseph); Yakob, L. (Laith); Bhandari, P. (Priyanka); Undurraga, E.A. (Eduardo A.); Hernández-Leal, M.J. (María José); Naylor, N.R. (Nichola R.)Introduction: Limited information on costs and the cost-effectiveness of hospital interventions to reduce antibiotic resistance (ABR) hinder efficient resource allocation. Methods: We conducted a systematic literature review for studies evaluating the costs and cost-effectiveness of pharmaceutical and non-pharmaceutical interventions aimed at reducing, monitoring and controlling ABR in patients. Articles published until 12 December 2023 were explored using EconLit, EMBASE and PubMed. We focused on critical or high-priority bacteria, as defined by the WHO, and intervention costs and incremental cost-effectiveness ratio (ICER). Following Preferred Reporting Items for Systematic review and Meta-Analysis guidelines, we extracted unit costs, ICERs and essential study information including country, intervention, bacteria-drug combination, discount rates, type of model and outcomes. Costs were reported in 2022 US dollars ($), adopting the healthcare system perspective. Country willingness-to-pay (WTP) thresholds from Woods et al 2016 guided cost-effectiveness assessments. We assessed the studies reporting checklist using Drummond¿s method. Results: Among 20.958 articles, 59 (32 pharmaceutical and 27 non-pharmaceutical interventions) met the inclusion criteria. Non-pharmaceutical interventions, such as hygiene measures, had unit costs as low as $1 per patient, contrasting with generally higher pharmaceutical intervention costs. Several studies found that linezolid-based treatments for methicillin-resistant Staphylococcus aureus were cost-effective compared with vancomycin (ICER up to $21¿488 per treatment success, all 16 studies¿ ICERs
- A scoping research literature review to explore bereavement humor(2023) Knox, M. (Michelle); Wilson, D.M. (Donna M.); Chrzanowski, A.M. (Ana M.); Bykowski, K. (Kathleen); Errasti-Ibarrondo, M.B. (María Begoña)The death of a loved one is extremely impactful. Although much of the focus now on helping people who are experiencing bereavement grief is oriented to distinguishing complicated from non-complicated grief for early pharmaceutical or psychiatric treatment, lay bereavement support comprises a more common and thus highly important but often unrecognized consideration. A wide variety of lay bereavement programs with diverse components have come to exist. This scoping research literature review focused on bereavement humor, one possible component. Humor has long been recognized as an important social attribute. Researchers have found humor is important for lifting the spirits of ill people and for aiding healing or recovery. However, humor does not appear to have been recognized as a technique that could benefit mourners. A multi-database search revealed only 11 English-language research articles have been published in the last 25 years that focused in whole or in part on bereavement humour. Although minimal evidence exists, these studies indicate bereaved people often use humor and for a number of reasons. Unfortunately, no investigations revealed when and why bereavement humor may be inappropriate or unhelpful. Additional research, multi-cultural investigations in particular, are needed to establish humor as a safe and effective bereavement support technique to apply or to use. Bereavement humor could potentially be used more often to support grieving people and bereaved people should perhaps be encouraged to use humor in their daily lives.
- Semi-passive UHF RFID sensor tags: A comprehensive review(2023) Montiel-Nelson, J.A.(Juan A.); Berenguer-Pérez, R.J. (Roque José); Beriain, A. (Andoni); Solar, H. (Hector); Sosa, J. (Javier)This paper presents a comprehensive overview and analysis of the state-of-the-art (SoA) in semi-passive or Battery-Assisted (BAP) Ultra-High Frequency (UHF) Radio Frequency Identification (RFID) sensor tags compliant with EPC Global G2/ISO-18000C. These tags operate on the same communication principle as fully passive sensor tags but incorporate a battery or an energy harvesting module. This additional power source extends communication ranges and enables power demanding applications using low-power microcontrollers (MCUs) and higher-end sensors. This article also analyzes various key features, including tag integrated circuit (IC) architecture, types of energy harvesting modules, and communication range. The main conclusions are threefold. Firstly, selecting the appropriate tag IC requires a careful analysis of its features such as sensitivity, sensor interfaces, or data logging capabilities. For instance, among the solutions examined in the SoA, half of them opted for a tag IC capable of MCU communication via SPI or I2C buses. Secondly, it is essential to assess both the forward and backward communication links to leverage the sensitivity of the tag IC in BAP mode. Interestingly, only one-third of the SoA solutions achieved the theoretical communication range anticipated by the sensitivity of the tag IC. Finally, an energy budget analysis is required to ensure that the energy generation suffices to meet the energy requirements of the tag. While most solutions rely on batteries as the energy source and analyze battery lifespan, only a few studies employing energy harvesters conduct an energy budget analysis due to the additional complexity involved.
- Digital Twin for maintenance: A literature review highly cited paper.(Elsevier, 2020-12) Errandonea, I. (Itxaro); Beltran-Calaff, S. (Segio); Arrizabalaga-Juaristi, S. (Saioa)In recent years, Digital Twins (DT) have been implemented in different industrial sectors, in several applications areas such as design, production, manufacturing, and maintenance. In particular, maintenance is one of the most researched applications, as the impact of the execution of maintenance task may have a great impact in the business of the companies. For example, in sector such as energy or manufacturing, a maintenance activity can cause the shutdown of an entire production line, or in the case of a wind turbine inspection, may face the safety of an operator to measure a simple indicator. Hence, the application of more intelligent maintenance strategies can offer huge benefits. In this context, this paper focuses on the review of DT applications for maintenance, as no previous work has been found with this aim. For instance, both "Digital Twin" and "maintenance" concepts and strategies are described in detail, and then a literature review is carried out where these two concepts are involved. In addition to identifying and analyzing how DTs are currently being applied for maintenance, this paper also highlights future research lines and open issues.
- Prolactin and oxytocin(2023) Lo-Cascio, S. (Salvatore); Börner, C. (Corinna); Kodounis, M. (Michalis); Ratti, S. (Susanna); Messlinger, K. (Karl); Rivera-Mancilla, E. (Eduardo); Onan, D. (Dilara); Mikolajek, D. (David); Szewczyk, A.K. (Anna K.); Cernigliaro, F. (Federica); Aktürk, T. (Tülin); Ulutas, S. (Samiye); Vries, T. (T.) de; Ragaglini, C. (Chiara); Al-Hassany, L. (Linda); Tsanoula, S. (Sofia); Maassen-van-den-Brink, A. (Antoinette); Villino, R. (Rafael)Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuations in sex steroid hormones are involved in the sex dimorphism of migraine attacks. In addition, the pituitary-derived hormone prolactin and the hypothalamic neuropeptide oxytocin have been reported to play a modulating role in migraine and contribute to its sex-dependent differences. The current narrative review explores the relationship between these two hormones and the pathophysiology of migraine. We describe the physiological role of prolactin and oxytocin, its relationship to migraine and pain, and potential therapies targeting these hormones or their receptors.In summary, oxytocin and prolactin are involved in nociception in opposite ways. Both operate at peripheral and central levels, however, prolactin has a pronociceptive effect, while oxytocin appears to have an antinociceptive effect. Therefore, migraine treatment targeting prolactin should aim to block its effects using prolactin receptor antagonists or monoclonal antibodies specifically acting at migraine-pain related structures. This action should be local in order to avoid a decrease in prolactin levels throughout the body and associated adverse effects. In contrast, treatment targeting oxytocin should enhance its signalling and antinociceptive effects, for example using intranasal administration of oxytocin, or possibly other oxytocin receptor agonists. Interestingly, the prolactin receptor and oxytocin receptor are co-localized with estrogen receptors as well as calcitonin gene-related peptide and its receptor, providing a positive perspective on the possibilities for an adequate pharmacological treatment of these nociceptive pathways. Nevertheless, many questions remain to be answered. More particularly, there is insufficient data on the role of sex hormones in men and the correct dosing according to sex differences, hormonal changes and comorbidities. The above remains a major challenge for future development.
- Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID?(2023) Zabaleta, A. (Aintzane); Ruiz-Pablos, M. (Manuel); Paiva, B. (Bruno)Both myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) and long COVID (LC) are characterized by similar immunological alterations, persistence of chronic viral infection, autoimmunity, chronic inflammatory state, viral reactivation, hypocortisolism, and microclot formation. They also present with similar symptoms such as asthenia, exercise intolerance, sleep disorders, cognitive dysfunction, and neurological and gastrointestinal complaints. In addition, both pathologies present Epstein-Barr virus (EBV) reactivation, indicating the possibility of this virus being the link between both pathologies. Therefore, we propose that latency and recurrent EBV reactivation could generate an acquired immunodeficiency syndrome in three steps: first, an acquired EBV immunodeficiency develops in individuals with weak EBV HLA-II haplotypes, which prevents the control of latency I cells. Second, ectopic lymphoid structures with EBV latency form in different tissues (including the CNS), promoting inflammatory responses and further impairment of cell-mediated immunity. Finally, immune exhaustion occurs due to chronic exposure to viral antigens, with consolidation of the disease. In the case of LC, prior to the first step, there is the possibility of previous SARS-CoV-2 infection in individuals with weak HLA-II haplotypes against this virus and/or EBV.
- Impact of safinamide on patient-reported outcomes in Parkinson's disease(2023) Martí-Andrés, G. (Gloria); Atorrasagasti-Villar, A. (Ainhoa); Espinoza-Vinces, C. (Christian); Villino, R. (Rafael); Luquin-Piudo, M.R. (María Rosario)Introduction: Parkinson's disease (PD) is a chronic and progressive neurodegenerative condition due to the degeneration of nigral dopaminergic cells. Both motor and non-motor symptoms (NMS) of PD produce a marked impairment in PD patients' quality of life (QoL), but contrary to motor features, NMS do not improve with dopamine replacement. Novel therapeutic interventions for PD have successfully controlled most motor manifestations of PD, but the management of NMS is still challenging. Since NMS have a negative impact on the QoL of PD patients, researchers are currently looking for drugs that can modulate the activity of neurotransmitter systems other than dopamine in the hope that can alleviate NMS in PD. Among the recently approved drugs for patients experiencing fluctuations in motor symptoms, safinamide stands out as an effective add-on therapy to levodopa. Safinamide is a monoamine oxidase type-B inhibitor (MAOB-I), with proven efficacy in reducing motor fluctuations. Its distinctive mechanism of action impacts dopaminergic pathways via MAOB inhibition and glutamatergic pathways by blocking sodium and calcium channels. Findings from Phase III clinical trials, meta-analysis, post-hoc analysis, and real-life experiences indicate that safinamide benefits motor symptoms such as tremor, bradykinesia, rigidity, and gait. Additionally, it shows promise for improving NMS like fatigue, pain, mood, and sleep disturbances in patients with PD.Areas Covered: In this article, the authors explore the impact of safinamide on patient-reported outcomes in PD. A thorough search was conducted on PubMed focusing on studies published between 2018 and 2023 in English. The inclusion criteria encompassed clinical trials, randomized controlled trials, systematic reviews, meta-analyses, and reviews. The search strategy revolved around the implementation of MeSH terms related to safinamide and its impact on the quality of life in PD.Conclusion: Our data strongly support the improving effect on QoL, reducing the disabling NMS reported in patients with PD.