This paper presents some initial theses of a wider study on Nicolas of Cusa¿s metaphysics of knowledge. It begins by quoting a text of maturity of the Cusan in which: a) the intellect is characterized as the first; b) knowledge is paired with the notion of manifestation; and c) it is noticed that self-knowledge leads to the knowledge of the Absolute creator. The quotation will lead us, then, to a notion of knowledge as interpretation of things, insofar as they acquire meaning in the human mind.