Promoter hypermethylation of the AE2/SLC4A2 gene in PBC
| dadun.citation.endingPage | 153 | es_ES |
| dadun.citation.number | 3 | es_ES |
| dadun.citation.publicationName | JHEP Reports | es_ES |
| dadun.citation.startingPage | 145 | es_ES |
| dadun.citation.volume | 1 | es_ES |
| dc.contributor.author | Medina, J.F. (Juan Francisco) | |
| dc.contributor.author | Saez, E. (Elena) | |
| dc.contributor.author | Melero, S. (Saida) | |
| dc.contributor.author | Prieto, J. (Jesús) | |
| dc.contributor.author | Arenas, F. (Fabián) | |
| dc.contributor.author | Parés, A. (Albert) | |
| dc.contributor.author | Hervias, I. (Isabel) | |
| dc.date.accessioned | 2021-10-27T07:45:35Z | |
| dc.date.available | 2021-10-27T07:45:35Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Primary biliary cholangitis (PBC) is a chronic immuneassociated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly middle-aged women. Patients with PBC exhibit reduced expression of the AE2/SLC4A2 gene. Herein, we found that AE2 promoter regions are hypermethylated in the liver and peripheral blood mononuclear cells of patients with PBC. This increased methylation is associated with downregulated AE2-gene expression, which might contribute to the pathogenesis of PBC. Therefore, novel epigenetic targets may improve treatment in patients with PBC who respond poorly to current pharmacological therapies. | es_ES |
| dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
| dc.description.sponsorship | This work was supported by an agreement between FIMA and the “UTE for CIMA Project”, the Spanish Ministry of Education and Science SAF2009- 11538 (JFM) and the Carlos III Institute of Health-CIBEREHD Program (JFM, JP, AP). | es_ES |
| dc.identifier.citation | Arenas, F. (Fabián); Hervias, I. (Isabel); Saez, E. (Elena); et al. "Promoter hypermethylation of the AE2/SLC4A2 gene in PBC". JHEP Reports. 1 (3), 2019, 145 - 153 | es_ES |
| dc.identifier.doi | 10.1016/j.jhepr.2019.05.006 | |
| dc.identifier.issn | 2589-5559 | |
| dc.identifier.uri | https://hdl.handle.net/10171/62283 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | Elsevier | es_ES |
| dc.relation.center | CIMA (Centro de Investigación Médica Aplicada) | |
| dc.relation.department | Terapia génica - Terapia génica hepatitis virales | |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | AE2 chloride | es_ES |
| dc.subject | Bicarbonate exchanger | es_ES |
| dc.subject | Cholestasis | es_ES |
| dc.subject | DNA methylation | es_ES |
| dc.subject | Epigenetic repression | es_ES |
| dc.subject | Primary biliary cholangitis | es_ES |
| dc.subject | Cirrhosis | es_ES |
| dc.title | Promoter hypermethylation of the AE2/SLC4A2 gene in PBC | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dspace.entity.type | Publication | es |
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