Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Aranguren, X.L. (Xabier L.) | - |
dc.creator | Pelacho, B. (Beatriz) | - |
dc.creator | Peñuelas-Sanchez, I. (Ivan) | - |
dc.creator | Abizanda-Sarasa, G. (Gloria) | - |
dc.creator | Uriz, M. (Maialen) | - |
dc.creator | Ecay, M. (Margarita) | - |
dc.creator | Collantes, M. (María) | - |
dc.creator | Araña, M. (Miriam) | - |
dc.creator | Beerens, M. (Manu) | - |
dc.creator | Coppiello, G. (Giulia) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Perez-Ilzarbe, M. (Maitane) | - |
dc.creator | Andreu, E.J. (Enrique José) | - |
dc.creator | Luttun, A. (Aernout) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.date.accessioned | 2010-09-27T09:43:38Z | - |
dc.date.available | 2010-09-27T09:43:38Z | - |
dc.date.issued | 2010-08-17 | - |
dc.identifier.citation | Cell Transplant 2011;20(2):259-269. | es_ES |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | https://hdl.handle.net/10171/13042 | - |
dc.description.abstract | There is a need for comparative studies to determine which cell types are better candidates to remedy ischemia. Here, we compared human AC133+ cells and Multipotent Adult Progenitor Cells (hMAPC) in a mouse model reminiscent of critical limb ischemia. hMAPC or hAC133+ cell transplantation induced a significant improvement in tissue perfusion (measured by microPET) 15 days post-transplantation compared to controls. This improvement persisted for 30 days in hMAPC-treated but not in hAC133+-injected animals. While transplantation of hAC133+ cells promoted capillary growth, hMAPC transplantation also induced collateral expansion, decreased muscle necrosis/fibrosis and improved muscle regeneration. Incorporation of differentiated hAC133+ or hMAPC progeny into new vessels was limited, however, a paracrine angio/arteriogenic effect was demonstrated in animals treated with hMAPC. Accordingly, hMAPC-, but not hAC133+-conditioned media, stimulated vascular cell proliferation and prevented myoblast, endothelial and smooth muscle cell apoptosis in vitro. Our study suggests that although hAC133+ cell and hMAPC transplantation bothcontribute to vascular regeneration in ischemic limbs, hMAPC exert a more robust effect through trophic mechanisms, which translated into collateral and muscle fiber regeneration. This, in turn, conferred tissue protection and regeneration with longer-term functional improvement. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cognizant Communication Corporation | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/222995/EU | - |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Mapc | es_ES |
dc.subject | AC133+ cells | es_ES |
dc.subject | Critical limb ischemia | es_ES |
dc.subject | Stem cells | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Multipotent Adult Progenitor Cells | es_ES |
dc.subject | Ischemia | es_ES |
dc.subject | Micropet | es_ES |
dc.subject | Myoblast | es_ES |
dc.title | MAPC transplantation confers a more durable benefit than AC133+ cell transplantation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3727/096368910X516592 | - |
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