Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Mazo, M. (Manuel) | - |
dc.creator | Gavira, J.J. (Juan José) | - |
dc.creator | Abizanda-Sarasa, G. (Gloria) | - |
dc.creator | Moreno, C. (Cristina) | - |
dc.creator | Ecay, M. (Margarita) | - |
dc.creator | Soriano, M. (Mario) | - |
dc.creator | Aranda, P. (P.) | - |
dc.creator | Collantes, M. (María) | - |
dc.creator | Alegria, E. (Eduardo) | - |
dc.creator | Merino, J. (Juana) | - |
dc.creator | Peñuelas-Sanchez, I. (Ivan) | - |
dc.creator | Garcia-Verdugo, J.M. (José Manuel) | - |
dc.creator | Pelacho, B. (Beatriz) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.date.accessioned | 2010-10-19T07:39:24Z | - |
dc.date.available | 2010-10-19T07:39:24Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | Mazo M, Gavira JJ, Abizanda G, Moreno C, Ecay M, Soriano M, et al. Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat. Cell Transplant 2010;19(3):313-328. | es_ES |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | https://hdl.handle.net/10171/13519 | - |
dc.description.abstract | The aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant. Five weeks after induction of MI, rats were allocated to receive intramyocardial injection of 106 GFP-expressing cells (BM-MNC or MSC) or medium as control. Heart function (echocardiography and 18F-FDG-microPET) and histological studies were performed 3 months after transplantation and cell fate was analyzed along the experiment (1 and 2 weeks and 1 and 3 months). The main findings of this study were that both BM-derived populations, BM-MNC and MSC, induced a long-lasting (3 months) improvement in LVEF (BM-MNC: 26.61 ± 2.01% to 46.61 ± 3.7%, p < 0.05; MSC: 27.5 ± 1.28% to 38.8 ± 3.2%, p < 0.05) but remarkably, only MSC improved tissue metabolism quantified by 18FFDG uptake (71.15 ± 1.27 to 76.31 ± 1.11, p < 0.01), which was thereby associated with a smaller infarct size and scar collagen content and also with a higher revascularization degree. Altogether, results show that MSC provides a long-term superior benefit than whole BM-MNC transplantation in a rat model of chronic MI. | es_ES |
dc.description.sponsorship | http://dx.doi.org/10.3727/096368909X480323 | - |
dc.language.iso | eng | es_ES |
dc.publisher | Cognizant Communication Corporation | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/222995 | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Bone marrow stem cells | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Chronic myocardial infarction | es_ES |
dc.subject | Cardiac remodeling | es_ES |
dc.title | Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.