Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.
Keywords:
Alzheimer's disease
chaperone
histone deacetylase
phenylbutyrate
amyloid and Tau
amyloid
Tau
4-phenylbutyrate
multi-target mechanism
enzymes
therapeutic effects
Publisher:
Bentham Science Publ LTD
Citation:
Cuadrado-Tejedor M, Garcia-Osta A, Ricobaraza A, Oyarzabal J, Franco R. Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease. Curr Med Chem 2011;18(36):5545-5553.
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