Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma

Prior, C. (Celia); Perez-Gracia, J.L. (Jose Luis); Garcia-Donas, J. (Jesús); Rodriguez-Antona, C. (Cristina); Guruceaga, E. (Elizabeth); Esteban-Gutiérrez, E. (Emilio); Suárez, C. (Cristina); Castellano, D. (Daniel); Gonzalez-del-Alba, A. (Aránzazu); Lozano, M.D. (María Dolores); Carles, J. (Joan); Climent, M.A. (Miguel Ángel); Arranz, J.A. (Jose Ángel); Gallardo, E. (Enrique); Puente, J. (Javier); Bellmunt, J. (Joaquim); Gurpide, A. (Alfonso); Lopez-Picazo, J.M. (José M.); Gonzalez-Hernandez, A. (Alvaro); Mellado, B. (Begoña); Martinez, E. (Esther); Moreno, F. (Fernando); Font, A. (Albert); Calvo-González, A. (Alfonso)

Keywords:

Tissue microRNAs
Metastatic renal
Carcinoma

Issue Date:

2014

Publisher:

Public Library of Science

ISSN:

1932-6203

Citation:

Prior C, Pérez-Gracia JL, García-Donas J, Rodríguez-Antona C, Guruceaga E, Esteban E, et al. Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma. PLoS One. 2014 Jan 24;9(1):e86263

Abstract

We identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies.

URI:

https://hdl.handle.net/10171/35300

Appears in Collections:

DA - CUN - Bioquímica clínica - Artículos de revista
DA - CUN - Oncología médica - Artículos de revista

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