Full metadata record
DC Field | Value | Language |
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dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Zazpe, I. (Itziar) | - |
dc.creator | Razquin, C. (Cristina) | - |
dc.creator | Sanchez-Tainta, A. (Ana) | - |
dc.creator | Corella, D. (Dolores) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.creator | Toledo, E. (Estefanía) | - |
dc.creator | Ros, E. (Emilio) | - |
dc.creator | Muñoz, M.A. (Miguel Angel) | - |
dc.creator | Recondo, J. (Javier) | - |
dc.creator | Gomez-Gracia, E. (Enrique) | - |
dc.creator | Fiol, M. (Miquel) | - |
dc.creator | Lapetra, J. (José) | - |
dc.creator | Buil-Cosiales, P. (Pilar) | - |
dc.creator | Serra-Majem, L. (Luis) | - |
dc.creator | Pinto, X. (Xavier) | - |
dc.creator | Schröder, H. (Helmut) | - |
dc.creator | Tur, J.A. (Josep A.) | - |
dc.creator | Sorli, J.V. (Jose V.) | - |
dc.creator | Lamuela-Raventos, R.M. (Rosa Maria) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.date.accessioned | 2014-11-24T11:24:12Z | - |
dc.date.available | 2014-11-24T11:24:12Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Martínez-González M.A, Zazpe I, Razquin C, Sánchez-Tainta A, Corella D, Salas-Salvadó J, et al. Empirically derived food patterns and the risk of total mortality and cardiovascular events in the predimed study. Clin Nutr. 2014 Sep 16. pii: S0261-5614(14)00233-7. | es_ES |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37086 | - |
dc.description.abstract | BACKGROUND & AIMS: There is little evidence on post hoc-derived dietary patterns (DP) and all-cause mortality in Southern-European populations. Furthermore, the potential effect modification of a DP by a nutritional intervention has not been sufficiently assessed. We assessed the association between a posteriori defined baseline major DP and total mortality or cardiovascular events within each of the three arms of a large primary prevention trial (PREDIMED) where participants were randomized to two active interventions with Mediterranean-type diets or to a control group (allocated to a low-fat diet). DESIGN: We followed-up 7216 participants for a median of 4.3 years. A validated 137-item food-frequency questionnaire was administered. Baseline DP were ascertained through factor analysis based on 34 predefined groups. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) for cardiovascular disease (CVD) or mortality across quartiles of DP within each of the three arms of the trial. RESULTS: We identified two major baseline DP: the first DP was rich in red and processed meats, alcohol, refined grains and whole dairy products and was labeled Western dietary pattern (WDP). The second DP corresponded to a "Mediterranean-type" dietary pattern (MDP). During follow-up, 328 participants died. After controlling for potential confounders, higher baseline adherence to the MDP was associated with lower risk of CVD (adjusted HR for fourth vs. first quartile: 0.52; 95% CI (Confidence Interval): 0.36, 0.74; p-trend <0.001) and all-cause mortality (adjusted HR: 0.53; 95% CI: 0.38, 0.75; p-trend <0.001), regardless of the allocated arm of the trial. An increasing mortality rate was found across increasing quartiles of the WDP in the control group (allocated to a low-fat diet), though the linear trend was not statistically significant (p = 0.098). CONCLUSIONS: Higher adherence to an empirically-derived MDP at baseline was associated with a reduced risk of CVD and mortality in the PREDIMED trial regardless of the allocated arm. The WDP was not associated with higher risk of mortality or cardiovascular events. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cardiovascular risk | es_ES |
dc.subject | Dietary pattern | es_ES |
dc.subject | Mediterranean diet | es_ES |
dc.subject | Mortality | es_ES |
dc.subject | Predimed | es_ES |
dc.title | Empirically derived food patterns and the risk of total mortality and cardiovascular events in the predimed study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.clnu.2014.09.006 | es_ES |
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