Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Mishima, Y. (Yuji) | - |
dc.creator | Paiva, B. (Bruno) | - |
dc.creator | Shi, J. (Jiantao) | - |
dc.creator | Park, J. (Jihye) | - |
dc.creator | Manier, S. (Salomon) | - |
dc.creator | Takagi, S. (Satoshi) | - |
dc.creator | Massoud, M. (Mira) | - |
dc.creator | Perilla-Glen, A. (Adriana) | - |
dc.creator | Aljawai, Y. (Yosra) | - |
dc.creator | Huynh, D. (Daisy) | - |
dc.creator | Roccaro, A.M. (Aldo M.) | - |
dc.creator | Sacco, A. (Antonio) | - |
dc.creator | Capelletti, M. (Marzia) | - |
dc.creator | Detappe, A. (Alexandre) | - |
dc.creator | Alignani, D. (Diego) | - |
dc.creator | Anderson, K.C. (K.C.) | - |
dc.creator | Munshi, N.C. (Nikhil C.) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Lohr, J.G. (Jens G.) | - |
dc.creator | Ha, G. (Gavin) | - |
dc.creator | Freeman, S.S. (Samuel S.) | - |
dc.creator | Van-Allen, E.M. (Eliezer M.) | - |
dc.creator | Adalsteinsson, V.A. (Viktor A.) | - |
dc.creator | Michor, F. (Franziska) | - |
dc.creator | San-Miguel, J.F. (Jesús F.) | - |
dc.creator | Ghobrial, I.M. (Irene M.) | - |
dc.date.accessioned | 2018-05-09T07:19:47Z | - |
dc.date.available | 2018-05-09T07:19:47Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Mishima, Y. (Yuji); Paiva, B. (Bruno); Shi, J. (Jiantao); et al. "The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma". Cell Reports. 19, 2017, 218 - 224 | es |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://hdl.handle.net/10171/52173 | - |
dc.description.abstract | The development of sensitive and non-invasive ‘‘liquid biopsies’’ presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we have analyzed the genomic landscape of CTCs from 29 MM patients, including eight cases with matched/paired bone marrow (BM) tumor cells. Our results show that 100% of clonal mutations in patient BM were detected in CTCs and that 99% of clonal mutations in CTCs were present in BM MM. These include typical driver mutations in MM such as in KRAS, NRAS, or BRAF. These data suggest that BM and CTC samples have similar clonal structures, as discordances between the two were restricted to subclonal mutations. Accordingly, our results pave the way for potentially less invasive mutation screening of MM patients through characterization of CTCs. | es_ES |
dc.description.sponsorship | This work was supported in part by the Leukemia and Lympoma Society Specialized Center of Research (SCOR) grant and NIH R01 CA181683-01A1. This study was also supported by the Cooperative Research Thematic Network grants RD12/0036/0058 (CIBERONC); Instituto de Salud Carlos III, Spain, Instituto de Salud Carlos III/Subdireccio´ n General de Investigacio´ n Sanitaria (FIS: PI060339; 06/1354; 02/0905; 01/0089/01-02; PS09/01897/ 01370; G03/136; Sara Borrell: CD13/00340); and Asociacio´ n Espan˜ ola Contra el Ca´ ncer (GCB120981SAN). The study was also supported internationally by the International Myeloma Foundation Junior Grant Proposal, the Multiple Myeloma Research Foundation research fellow award, the American Association for Cancer Research (15-40-38-PAIV), and a European Research Council Starting Grant (680200-MYELOMANEXT). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/680200/EU | - |
dc.relation | info:eu-repo/grantAgreement/NIH/NATIONAL_CANCER_INSTITUTE/5R01CA181683-04/US | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Hematología | es_ES |
dc.subject | Multiple myeloma | es_ES |
dc.title | The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://linkinghub.elsevier.com/retrieve/pii/S2211124717303571 | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2017.03.025 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.