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dc.creatorBragard, J. (Jean)-
dc.creatorSankarankutty, A.C. (Aparna C.)-
dc.creatorSachse, F.B. (Frank B.)-
dc.date.accessioned2021-10-29T11:49:40Z-
dc.date.available2021-10-29T11:49:40Z-
dc.date.issued2019-
dc.identifier.citationBragard, J. (Jean); Sankarankutty, A.C. (Aparna C.); Sachse, F.B. (Frank B.). "Extended bidomain modeling of defibrillation: quantifying virtual electrode strengths in fibrotic myocardium". Frontiers in Physiology. 10, 2019, 337es_ES
dc.identifier.issn1664-042X-
dc.identifier.urihttps://hdl.handle.net/10171/62295-
dc.description.abstractDefibrillation is a well-established therapy for atrial and ventricular arrhythmia. Here, we shed light on defibrillation in the fibrotic heart. Using the extended bidomain model of electrical conduction in cardiac tissue, we assessed the influence of fibrosis on the strength of virtual electrodes caused by extracellular electrical current. We created one-dimensional models of rabbit ventricular tissue with a central patch of fibrosis. The fibrosis was incorporated by altering volume fractions for extracellular, myocyte and fibroblast domains. In our prior work, we calculated these volume fractions from microscopic images at the infarct border zone of rabbit hearts. An average and a large degree of fibrosis were modeled. We simulated defibrillation by application of an extracellular current for a short duration (5 ms). We explored the effects of myocyte-fibroblast coupling, intra-fibroblast conductivity and patch length on the strength of the virtual electrodes present at the borders of the normal and fibrotic tissue. We discriminated between effects on myocyte and fibroblast membranes at both borders of the patch. Similarly, we studied defibrillation in two-dimensional models of fibrotic tissue. Square and disk-like patches of fibrotic tissue were embedded in control tissue. We quantified the influence of the geometry and fibrosis composition on virtual electrode strength. We compared the results obtained with a square and disk shape of the fibrotic patch with results from the one-dimensional simulations. Both, one- and two-dimensional simulations indicate that extracellular current application causes virtual electrodes at boundaries of fibrotic patches. A higher degree of fibrosis and larger patch size were associated with an increased strength of the virtual electrodes. Also, patch geometry affected the strength of the virtual electrodes. Our simulations suggest that increased fibroblast-myocyte coupling and intra-fibroblast conductivity reduce virtual electrode strength. However, experimental data to constrain these modeling parameters are limited and thus pinpointing the magnitude of the reduction will require further understanding of electrical coupling of fibroblasts in native cardiac tissues. We propose that the findings from our computational studies are important for development of patient-specific protocols for internal defibrillators.es_ES
dc.description.sponsorshipJB acknowledges the support of a Fulbright Fellowship for his stay at the Nora Eccles Harrison Cardiovascular Research and Training Institute at the University of Utah and also partial support through a grant project by the Spanish Ministerio de Economía y Competitividad (MINECO) under number SAF2014-58286-C2-2-R. FS acknowledges financial support from the Nora Eccles Treadwell Foundation and the National Institutes of Health (R01 HL 135077 and R01 HL 132067).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media SAes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDefibrillationes_ES
dc.subjectCardiac tissuees_ES
dc.subjectFibrosises_ES
dc.subjectComputational modelinges_ES
dc.subjectMultidomain modelinges_ES
dc.titleExtended bidomain modeling of defibrillation: quantifying virtual electrode strengths in fibrotic myocardiumes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).es_ES
dc.identifier.doi10.3389/fphys.2019.00337-
dadun.citation.publicationNameFrontiers in Physiologyes_ES
dadun.citation.startingPage337es_ES
dadun.citation.volume10es_ES

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