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dc.creatorDominguez, L.J. (Ligia J.)-
dc.creatorGea, A. (Alfredo)-
dc.creatorRuiz-Estigarribia, L. (Liz)-
dc.creatorSayon-Orea, C. (Carmen)-
dc.creatorFresan, U. (Ujue)-
dc.creatorBarbagallo, M. (Mario)-
dc.creatorRuiz-Canela, M. (Miguel)-
dc.creatorMartinez-Gonzalez, M. A. (Miguel Ángel)-
dc.date.accessioned2022-02-22T07:07:54Z-
dc.date.available2022-02-22T07:07:54Z-
dc.date.issued2021-
dc.identifier.citationDominguez, L. J.; Gea-Sánchez, A. (Alfredo); Ruiz-Estigarribia, L. (Liz María); et al. "Low dietary magnesium and overweight/obesity in a Mediterranean population: a detrimental synergy for the development of hypertension. The SUN Project". Nutrients. 13 (1), 2021, 125es
dc.identifier.issn2072-6643-
dc.identifier.urihttps://hdl.handle.net/10171/62947-
dc.description.abstractHypertension is the strongest independent modifiable risk factor for cardiovascular disease. We aimed to investigate the association of magnesium intake with incident hypertension in a Mediterranean population, and the potential modification of this association by body mass index (BMI). We assessed 14,057 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (67.0% women) initially free of hypertension. At baseline, a validated 136-item food frequency questionnaire was administered. We used Cox models adjusted for multiple socio-demographic, anthropometric, and lifestyle factors, and prevalent conditions present at baseline. Among a mean 9.6 years of follow-up we observed 1406 incident cases of medically diagnosed hypertension. An inverse association in multivariable-adjusted models was observed for progressively higher magnesium intake up to 500 mg/d vs. intake < 200 mg/d, which was greater among those with a BMI > 27 kg/m(2). Lean participants with magnesium intake < 200 mg/d vs. >200 mg/d also had a higher risk of incident hypertension. Adherence to the Mediterranean diet did not modify these associations. In conclusion, dietary magnesium intake < 200 mg/d was independently associated with a higher risk of developing hypertension in a Mediterranean cohort, stronger for overweight/obese participants. Our results emphasize the importance of encouraging the consumption of magnesium-rich foods (vegetables, nuts, whole cereals, legumes) in order to prevent hypertension.-
dc.description.sponsorshipThe SUN Project has received funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045), CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, and PI17/01795.-
dc.language.isoen-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectMagnesium-
dc.subjectHypertension-
dc.subjectObesity-
dc.subjectOverweight-
dc.subjectDiet-
dc.subjectCohort studies-
dc.titleLow dietary magnesium and overweight/obesity in a Mediterranean population: a detrimental synergy for the development of hypertension. The SUN Project-
dc.typeinfo:eu-repo/semantics/article-
dc.description.noteThis article is an open access article distributed under the terms and con- ditions of the Creative Commons At- tribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)-
dc.identifier.doi10.3390/nu13010125-
dadun.citation.number1-
dadun.citation.publicationNameNutrients-
dadun.citation.startingPage125-
dadun.citation.volume13-

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