Full metadata record
DC Field | Value | Language |
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dc.creator | Inchaurraga-Casadamon, L. (Laura) | - |
dc.creator | López, A. (Andrés) | - |
dc.creator | Abdulkarim, M. (Muthanna) | - |
dc.creator | Gumbleton, M. (Mark) | - |
dc.creator | Quincoces, G. (Gemma) | - |
dc.creator | Peñuelas-Sanchez, I. (Ivan) | - |
dc.creator | Martin-Arbella, N. (Nekane) | - |
dc.creator | Irache, J.M. (Juan Manuel) | - |
dc.date.accessioned | 2022-06-09T12:16:47Z | - |
dc.date.available | 2022-06-09T12:16:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Inchaurraga-Casadamon, L. (Laura); Martínez-López, A.L. (Ana L.); Abdulkarim, M. (Muthanna); et al. "Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate". International Journal of Pharmaceutics: X. 1, 2019, 100006 | es |
dc.identifier.issn | Elsevier BV | - |
dc.identifier.uri | https://hdl.handle.net/10171/63634 | - |
dc.description.abstract | The aim of this work was to evaluate the mucus-permeating properties of nanocarriers using zein nanoparticles (NPZ) coated with a Gantrez® AN-thiamine conjugate (GT). NPZ were coated by incubation at different GT-tozein ratios: 2.5% coating with GT (GT-NPZ1), 5% (GT-NPZ2) and 10% (GT-NPZ3). During the process, the GT conjugate formed a polymer layer around the surface of zein nanoparticles. For GT-NPZ2, the thickness of this corona was estimated between 15 and 20 nm. These nanocarriers displayed a more negative zeta potential than uncoated NPZ. The diffusivity of nanoparticles was evaluated in pig intestinal mucus by multiple particle tracking analysis. GT-NPZ2 displayed a 28-fold higher diffusion coefficient within the mucus layer than NPZ particles. These results align with in vivo biodistribution studies in which NPZ displayed a localisation restricted to the mucus layer, whereas GT-NPZ2 were capable of reaching the intestinal epithelium. The gastro-intestinal transit of mucoadhesive (NPZ) and mucus-permeating nanoparticles (GT-NPZ2) was also found to be different. Thus, mucoadhesive nanoparticles displayed a significant accumulation in the stomach of animals, whereas mucus-penetrating nanoparticles appeared to exit the stomach more rapidly to access the small intestine of animals | es_ES |
dc.description.sponsorship | This work was supported by the European Community's Seventh Framework Programme [FP7/2007-2013] ALEXANDER project (grant agreement n° NMP-2011-1.2-2-280761). Furthermore, Laura Inchaurraga acknowledges “Asociación de Amigos” of the University of Navarra for the financial support. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Zein | es_ES |
dc.subject | Nanoparticles | es_ES |
dc.subject | Thiamine | es_ES |
dc.subject | Oral delivery | es_ES |
dc.subject | Coating | es_ES |
dc.subject | Mucus permeating | es_ES |
dc.title | Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | es_ES |
dc.identifier.doi | 10.1016/j.ijpx.2019.100006 | - |
dadun.citation.publicationName | International Journal of Pharmaceutics: X | es_ES |
dadun.citation.startingPage | 100006 | es_ES |
dadun.citation.volume | 1 | es_ES |
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