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dc.creatorBarrio-Barrio, J. (Jesús)-
dc.creatorBonet-Farriol, M.E. (María Elvira)-
dc.creatorGaldós, M. (Marta)-
dc.creatorNoval, S. (Susana)-
dc.creatorPueyo, V. (Victoria)-
dc.creatorBreeze, C.E. (Charles E.)-
dc.creatorSantos, J.L. (José Luis)-
dc.creatorAlfonso-Bartolozzi, B. (Belén)-
dc.creatorRecalde, S. (Sergio)-
dc.creatorPatiño-García, A. (Ana)-
dc.identifier.citationBarrio-Barrio, J. (Jesús); Bonet-Farriol, M.E. (María Elvira); Galdós, M. (Marta); et al. "HGF-rs12536657 and ocular biometric parameters in hyperopic children, emmetropic adolescents, and young adults: A multicenter quantitative trait study". Journal of Ophthalmology. 2019, 2019, 7454250es
dc.description.abstractIntroduction. Even though ocular refractive state is highly heritable and under strong genetic control, the identification of susceptibility genes remains a challenge. Several HGF (hepatocyte growth factor) gene variants have been associated with ocular refractive errors and corneal pathology. Purpose. Here, we assess the association of an HGF gene variant, previously reported as associated with hyperopia, and ocular biometric parameters in a multicenter Spanish cohort. Methods. An observational prospective multicenter cross-sectional study was designed, including a total of 403 unrelated subjects comprising 188 hyperopic children (5 to 17 years) and 2 control groups: 52 emmetropic adolescents (13 to 17 years) and 163 emmetropic young adults (18 to 28 years). Each individual underwent a comprehensive eye examination including cycloplegic refraction, and topographic and ocular biometric analysis. Genomic DNA was extracted from oral swabs. HGF single nucleotide polymorphism (SNP) rs12536657 was genotyped. Genotypic, allelic, and logistic regression analyses were performed comparing the different groups. A quantitative trait association test analyzing several biometric parameters was also performed using generalized estimating equations (GEEs) adjusting for age and gender. Results. No association between rs12536657 and hyperopia was found through gender-adjusted logistic regression comparing the hyperopic children with either of the two control groups. Significant associations between mean topographic corneal curvature and rs12536657 for G/ A (slope � +0.32; CI 95%: 0.04–0.60; p � 0.023) and A/A (slope � +0.76; CI 95%: 0.12–1.40; p � 0.020) genotypes were observed with the age- and gender-adjusted univariate GEE model. Both flat and steep corneal topographic meridians were also significantly associated with rs12536657 for the G/A and A/A genotypes. No association was found between rs12536657 and any other topographic or biometric measurements. Conclusions. Our results support a possible role for HGF gene variant rs12536657 in corneal curvature in our population. To our knowledge, this is the first multicenter quantitative trait association study of HGF genotypes and ocular biometric parameters comprising a pediatric cohort.es_ES
dc.description.sponsorshipThis study has been funded in part by a research grant within the University of Navarra research program (PIUNA: 8 Journal of Ophthalmology Programa de Investigacion Universidad de Navarra ´ 13108503).es_ES
dc.publisherHindawi Limitedes_ES
dc.subjectOcular refractive statees_ES
dc.subjectGenetic controles_ES
dc.subjectHGF (hepatocyte growth factor)es_ES
dc.subjectGene variantses_ES
dc.titleHGF-rs12536657 and ocular biometric parameters in hyperopic children, emmetropic adolescents, and young adults: A multicenter quantitative trait studyes_ES
dc.description.noteThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedes_ES
dadun.citation.publicationNameJournal of Ophthalmologyes_ES

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