Full metadata record
DC Field | Value | Language |
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dc.creator | Cross, A.R. (Amy R.) | - |
dc.creator | Andrea, C.E. (Carlos Eduardo) de | - |
dc.creator | Villalba-Esparza, M. (María) | - |
dc.creator | Landecho, M.F. (Manuel F.) | - |
dc.creator | Cerundolo, L. (Lucia) | - |
dc.creator | Weeratunga, P. (Praveen) | - |
dc.creator | Etherington, R.E. (Rachel E.) | - |
dc.creator | Denney, L. (Laura) | - |
dc.creator | Ogg, G. (Graham) | - |
dc.creator | Ho, L.P. (Ling-Pei) | - |
dc.creator | Roberts, I.S.D. (Ian S. D.) | - |
dc.creator | Hester, J. (Joanna) | - |
dc.creator | Klenerman, P. (Paul) | - |
dc.creator | Melero, I. (Ignacio) | - |
dc.creator | Sansom, S.N. (Stephen N.) | - |
dc.creator | Issa, F. (Fadi) | - |
dc.date.accessioned | 2023-04-18T08:45:07Z | - |
dc.date.available | 2023-04-18T08:45:07Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Cross, A. R.; De Andrea, C. (Carlos Eduardo); Villalba-Esparza, M. (María); et al. "Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury". JCI Insight. 8 (2), 2023, e157837 | es |
dc.identifier.issn | 2379-3708 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65968 | - |
dc.description.abstract | Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways, and genes present across the spectrum of histopathological damage in COVID-19-affected lung tissue. We applied correlation network-based approaches to deconvolve gene expression data from 46 areas of interest covering more than 62,000 cells within well-preserved lung samples from 3 patients. Despite substantial interpatient heterogeneity, we discovered evidence for a common immune-cell signaling circuit in areas of severe tissue that involves crosstalk between cytotoxic lymphocytes and pro-inflammatory macrophages. Expression of IFNG by cytotoxic lymphocytes was associated with induction of chemokines, including CXCL9, CXCL10, and CXCL11, which are known to promote the recruitment of CXCR3+ immune cells. The TNF superfamily members BAFF (TNFSF13B) and TRAIL (TNFSF10) were consistently upregulated in the areas with severe tissue damage. We used published spatial and single-cell SARS-CoV-2 data sets to validate our findings in the lung tissue from additional cohorts of patients with COVID-19. The resulting model of severe COVID-19 immune-mediated tissue pathology may inform future therapeutic strategies. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.title | Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. | - |
dc.identifier.doi | 10.1172/jci.insight.157837 | - |
dadun.citation.number | 2 | - |
dadun.citation.publicationName | JCI Insight | - |
dadun.citation.startingPage | e157837 | - |
dadun.citation.volume | 8 | - |
dc.identifier.pmid | 36472908 | - |
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