This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
Guallara, M.P. (María Pilar); Meiriño, R. (Rosa); Donat-Vargas, C.L. (Carolina Luisa); et al. "Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity". International Journal of Infectious Diseases. 97, 2020, 290 - 292
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for
SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to
distinctinoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data
support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk
of severe COVID-19.