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dc.creatorMontero, P. (Pilar)-
dc.creatorFlandes-Iparraguirre, M. (María)-
dc.creatorKuebler, B. (Brend)-
dc.creatorArán, B. (Begoña)-
dc.creatorLarequi-García, E. (Eduardo)-
dc.creatorAnaut, I. (Ilazki)-
dc.creatorCoppiello, G. (Giulia)-
dc.creatorAranguren, X.L. (Xabier L.)-
dc.creatorVeiga, A. (Anna)-
dc.creatorBasurte-Elorz, M.T. (María Teresa)-
dc.creatorGarcia-de-Yebenes, M. (Manuel)-
dc.creatorGavira, J.J. (Juan José)-
dc.creatorProsper-Cardoso, F. (Felipe)-
dc.creatorIglesias-García, O. (Olalla)-
dc.creatorMazo, M. (Manuel)-
dc.date.accessioned2023-09-27T10:00:50Z-
dc.date.available2023-09-27T10:00:50Z-
dc.date.issued2023-
dc.identifier.citationMontero, P. (Pilar); Flandes-Iparraguirre, M. (María); Kuebler, B. (Brend); et al. "Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene". Stem Cell Research. 71, 2023, 103189es_ES
dc.identifier.issn1876-7753-
dc.identifier.urihttps://hdl.handle.net/10171/67334-
dc.description.abstractTransthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) from a patient suffering familial transthyretin amyloid cardiomyopathy carrying a c.128G>A (p.Ser43Asn) mutation in the TTR gene. This iPSC line offers a useful resource to study the disease pathophysiology and a cell-based model for therapeutic discovery.es_ES
dc.description.sponsorshipThis work was supported by a Pfizer Global Medical Grant (GMG), ATTR-CM Global Research Program 67562235, and European Union’s H2020 research and innovation programme under grant agreement No 874827 (BRAV∃); Ministerio de Ciencia e Innovación CARDIOPRINT (PLEC2021-008127) and INVESTTRA (PID2022-142807OA-I00).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectTransthyretines_ES
dc.subjectAmyloid cardiomyopathyes_ES
dc.subjectLiver cellses_ES
dc.subjectPluripotent stem cell (iPSC)es_ES
dc.titleGeneration of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR genees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dc.identifier.doi10.1016/j.scr.2023.103189-
dadun.citation.publicationNameStem Cell Researches_ES
dadun.citation.startingPage103189es_ES
dadun.citation.volume71es_ES
dc.identifier.pmid37660554-

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