Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Montero, P. (Pilar) | - |
| dc.creator | Flandes-Iparraguirre, M. (María) | - |
| dc.creator | Kuebler, B. (Brend) | - |
| dc.creator | Arán, B. (Begoña) | - |
| dc.creator | Larequi-García, E. (Eduardo) | - |
| dc.creator | Anaut, I. (Ilazki) | - |
| dc.creator | Coppiello, G. (Giulia) | - |
| dc.creator | Aranguren, X.L. (Xabier L.) | - |
| dc.creator | Veiga, A. (Anna) | - |
| dc.creator | Basurte-Elorz, M.T. (María Teresa) | - |
| dc.creator | Garcia-de-Yebenes, M. (Manuel) | - |
| dc.creator | Gavira, J.J. (Juan José) | - |
| dc.creator | Prosper-Cardoso, F. (Felipe) | - |
| dc.creator | Iglesias-García, O. (Olalla) | - |
| dc.creator | Mazo, M. (Manuel) | - |
| dc.date.accessioned | 2023-09-27T10:00:50Z | - |
| dc.date.available | 2023-09-27T10:00:50Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.citation | Montero, P. (Pilar); Flandes-Iparraguirre, M. (María); Kuebler, B. (Brend); et al. "Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene". Stem Cell Research. 71, 2023, 103189 | es_ES |
| dc.identifier.issn | 1876-7753 | - |
| dc.identifier.uri | https://hdl.handle.net/10171/67334 | - |
| dc.description.abstract | Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) from a patient suffering familial transthyretin amyloid cardiomyopathy carrying a c.128G>A (p.Ser43Asn) mutation in the TTR gene. This iPSC line offers a useful resource to study the disease pathophysiology and a cell-based model for therapeutic discovery. | es_ES |
| dc.description.sponsorship | This work was supported by a Pfizer Global Medical Grant (GMG), ATTR-CM Global Research Program 67562235, and European Union’s H2020 research and innovation programme under grant agreement No 874827 (BRAV∃); Ministerio de Ciencia e Innovación CARDIOPRINT (PLEC2021-008127) and INVESTTRA (PID2022-142807OA-I00). | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Elsevier | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | Transthyretin | es_ES |
| dc.subject | Amyloid cardiomyopathy | es_ES |
| dc.subject | Liver cells | es_ES |
| dc.subject | Pluripotent stem cell (iPSC) | es_ES |
| dc.title | Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.description.note | This is an open access article under the CC BY-NC-ND license | es_ES |
| dc.identifier.doi | 10.1016/j.scr.2023.103189 | - |
| dadun.citation.publicationName | Stem Cell Research | es_ES |
| dadun.citation.startingPage | 103189 | es_ES |
| dadun.citation.volume | 71 | es_ES |
| dc.identifier.pmid | 37660554 | - |
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